Antibody Engineering for Rapid Pandemic Response: Discovering Potently Neutralizing COVID-19 Therapeutic Antibodies


Thursday, July 23, 2020
11:00 AM - 12:00 PM EDT (5:00 PM - 6:00 PM CEST)


Online Webinar
DBio COVID antibody flasks.png


In May 2020, Distributed Bio, and their therapeutics spin-out company Centivax, announced that three independent laboratories have confirmed that multiple Centivax antibody therapeutic candidates are potent neutralizers of the pandemic coronavirus. Viral neutralization directly demonstrates that the antibodies are able to completely block the novel coronavirus from infecting human cells.

How, exactly, was this achieved?

Attend this webinar to learn step by step how two technologies, the SuperHuman antibody library and Tumbler antibody optimization technology enabled this scientific achievement.

Jake Glanville and Sarah Ives will illustrate how the SuperHuman discovery technology was used to rapidly discover novel, fully human, high affinity, thermostable, SARS-CoV-2 neutralizing antibodies from a computationally optimized, fully human library comprised of ~76 billion sequence-unique antibodies. In just 4 weeks, they identified potent, novel therapeutics against the viral spike protein including broad-spectrum antibodies that bind tightly to and block both SARS and SARS-CoV-2.

They will also discuss how Distributed Bio’s Tumbler optimization technology was used to adapt 5 previously proven potently neutralizing and protective anti-SARS antibodies to target the novel pandemic COVID19-causing SAR-CoV-2 coronavirus. These well-established, super-potent anti-SARS antibodies could neutralize SARS and completely protect animals from SARS.

In addition to high affinity and potent neutralization, the antibodies have been engineered for optimal therapeutic properties, features built in to the SuperHuman design and Tumbler engineering process. These antibodies represent the cutting edge of modern antibody engineering. They are optimized for enhanced potency, thermostability, reduced immunogenicity, extended half-life, and enhanced safety. This makes them ideal therapeutic candidates for treating the novel pandemic coronavirus in both the hospital as well as prophylactic settings.

Find out how the SuperHuman and Tumbler technologies can be applied to accelerate your therapeutic programs. This webinar will include a case study, expert panel discussion and live Q&A.


Webinar Presenters & Panelist


Jake Glanville Headshot

Jake Glanville, PhD
Founding Partner, Chief Executive Officer, President, Chairman of the Board
Distributed Bio

Sarah Ives Headshot

Sarah Ives
Director of Contract Research
Distributed Bio

Katherine Vousden Headshot

Katherine Vousden, PhD
Science Director, Large Molecules
Charles River

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