Join us for part three of our four-part DART series, where we’ll talk about the two most common models for developmental and reproductive toxicity testing.
First, we’ll examine why the rat is well liked by researchers when studying in vivo DART testing. We’ll also take a look at the three most commonly used study designs – fertility and early embryonic development, embryo-fetal developmental toxicity (EFD), and pre/postnatal development – along with some infrequently used ones. You’ll learn about the aspects of study design, exposure assessment, dose selection and timing, and the advantages and drawbacks of including optional endpoints included in ICH S5.
Then, we will look at the most commonly used second species for EFD toxicity studies – the rabbit. See why they are the preferred model to studying vaccine candidates and why you should consider them for any study involving small or large molecules, or medical device testing. You’ll also learn how to determine exposure and tolerability, appropriate timing and conduct of dose-range studies for EFD toxicity studies, and study designs.
These will also be time after the presentation to get your questions answered by our presenters.
Mark Herberth, BSc
Associate Director, Developmental and Reproductive Toxicology
Louise Pouliot, BSc, DESS Tox
Director of Developmental, Reproductive and Juvenile Toxicology
View the other webinars in the series:
- ICH S5 - Updates and Implications (October 22)
- The Guidelines and Challenges of Performing NHP DART Studies (October 29)
- The Role of Dogs and Minipigs in DART Programs (November 12)
Have a scheduling conflict? Sign up even if you can't make it; we'll share the recording after.
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