Rodents and Rabbits – The Traditional DART Models

Date

Thursday, November 5, 2020
11:00 AM - 12:00 PM EST (5:00 PM - 6:00 PM CET)

Location

Online Webinar
two white rabbits next to one another

Overview

Join us for part three of our four-part DART series, where we’ll talk about the two most common models for developmental and reproductive toxicity testing.

First, we’ll examine why the rat is well liked by researchers when studying in vivo DART testing. We’ll also take a look at the three most commonly used study designs – fertility and early embryonic development, embryo-fetal developmental toxicity (EFD), and pre/postnatal development – along with some infrequently used ones. You’ll learn about the aspects of study design, exposure assessment, dose selection and timing, and the advantages and drawbacks of including optional endpoints included in ICH S5.

Then, we will look at the most commonly used second species for EFD toxicity studies – the rabbit. See why they are the preferred model to studying vaccine candidates and why you should consider them for any study involving small or large molecules, or medical device testing. You’ll also learn how to determine exposure and tolerability, appropriate timing and conduct of dose-range studies for EFD toxicity studies, and study designs.

These will also be time after the presentation to get your questions answered by our presenters.

 

Webinar Presenters

Mark Herberth Headshot

Mark Herberth, BSc
Associate Director, Developmental and Reproductive Toxicology
Charles River


Louise Pouliot Headshot

Louise Pouliot, BSc, DESS Tox
Director of Developmental, Reproductive and Juvenile Toxicology
Charles River

 

View the other webinars in the series:

 
Have a scheduling conflict? Sign up even if you can't make it; we'll share the recording after.
 

We are providing digital education options to keep you learning about topics you may be interested in. For more information, visit criver.com/digital-education.