Physicochemical (or physchem) testing is an integral requirement of product registration for agrochemicals, biocides, chemicals, and animal health products. Your timelines depend on our ability to meet commitments, regardless of challenges that may arise. With a full range of physicochemical testing capabilities to meet all regulatory requirements, Charles River has conducted many successful physchem programs for various agrochemical and pesticide classes, including insecticides, herbicides, fungicides and biocides. We have also worked with a wide variety of industrial chemicals, including dyes, flavor and fragrance substances, monomers, fluorinated chemicals, and inorganics. Data have been successfully accepted in support of numerous registrations throughout Europe, North America and Asia.
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Physicochemical Testing Services
- Partition coefficient
- Physical state
- Melting & freezing points
- Boiling point, relative density
- Surface tension
- Water solubility
- Organic solvent solubility
- Octanol/water partition coefficient
- Dissociation constant
- Oxidizing or reducing properties
- Rate of hydrolysis (cold)
- Spectra (UV, UV/Vis, IR, NMR, MS)
With a staff of more than 20 scientists dedicated to this discipline, our team completes approximately 300 analytical packages per year. We specialize in the physchem testing of a wide variety of materials, ranging from pure, stable substances up to complex mixtures and UVCBs as well as reactive matter. Our experts are skilled in a full array of analytical techniques, including LC, LC-MS, GC, GC-MS and ICPS-MS and can provide analytical support for both storage stability as well as physchem characterization.
Our scientists are also able to provide numerous physicochemical test expert statements, with or without the use of screening techniques such as DSC, to offer our clients the most economical testing strategies.
Storage Stability Testing
The storage stability and shelf life of a formulated product can be determined under a variety of specified storage conditions. Solid, liquid, semi-solid, and aerosol formulations can all be evaluated using real-time and accelerated storage stability testing. We have dedicated facilities to stress the material using monitored heat, humidity, or light parameters.
- HPLC (UV, LIF, fluorescence, refractive index, light scattering, electrochemical)
- GC (FID, NPD, TCD, ECD)
- LC-MS, GC-MS, GC/LC-MS-MS, time-of-flight (Q-ToF, IT-ToF)
- Capillary electrophoresis (UV, LIF)
- Dionex ion chromatograph (conductivity)
- ICP-OES (Optima™ 8000)
Frequently Asked Questions (FAQs) for Physicochemical Testing
Which guidelines cover the physicochemical testing of industrial chemicals?
A chemical is subject to the guidelines of the regulatory body with which it will be registered. The physchem testing at Charles River is designed to meet all relevant regulatory requirements of the major global markets, such as OECD Guidelines, TSCA and EPA guidelines.
Which guidelines cover the physicochemical and stability testing of agrochemical and biocidal products?
Similarly, the testing of an agrochemical or biocidal product must follow the guidelines of eventual regulatory body with which it is registered. The storage stability studies at Charles River are designed to meet all relevant regulatory requirements of the major global markets, including the European Union, the EPA and CIPAC.