Inflammatory Bowel Disease (IBD) refers to a group of chronic inflammatory diseases affecting the gastrointestinal (GI) tract. IBDs are classified into two major categories based on location of the GI tract being affected: ulcerative colitis (UC) mostly affects the colon and rectum, while Crohn’s disease (CD) can affect the entire GI tract.
Chemically-induced IBD models are used for their robustness, reproducibility and overall etiology of the disease, including some immunological and histological changes in the GI tract resembling the human disease. At Charles River, we currently offer the following chemically-induced IBD and GI inflammation models:
- Dextran sulfate sodium (DSS)-induced colitis models
- Acute DSS-induced colitis
- Chronic DSS-induced colitis
- Trinitrobenzene sulfonic acid (TNBS)-induced colitis model
- Poly I:C-induced intestinal inflammation model