High Quality Mouse Models for Biomedical Research
With more than 20 breeding facilities around the world, Charles River is the leading global supplier of standard mouse models for biomedical research.
Charles River stocks and strains are managed under the International Genetic Standardization (IGS) program, a unique program designed to manage the health and genetics of outbred and inbred strains on a global basis, ensuring that researchers worldwide have access to standardized models, regardless of the production location.
The Charles River Animal Model Evaluation Program allows you to assess the quality and compatibility of our animal models before making a commitment.
Inbred mice are defined as colonies produced by a minimum of 20 generations of brother-sister mating, traceable to a single founding pair. Charles River’s inbred mice are bred under the IGS program to help minimize subline divergence due to genetic drift and prevent genetic contamination by mismatings with other strains.
View Inbred Mice
Breeding outbred mice can be challenging. Outbred mice need to maintain diversity at the level of the individual while standardizing multiple production colonies that are geographically separated so that each colony has the same range of genetic variation.
Hybrid mice are created by crossing two inbred strains. This crossbreeding produces hybrid mice that are more resistant to sickness, have increased survival rate under stress, live longer, and have larger litters than the parental strains.
Charles River maintains a global portfolio of high quality immunodeficient animal models with varying levels of immunodeficiency and phenotypic characteristics.
Due to the challenges inherent in researching and developing anticancer therapeutics, it is important that you have the right oncology mouse models and resources available to you. Selecting the most appropriate oncology mouse model is a critical step when designing an oncology study.
The use of humanized mice as in vivo models has become common in studies for immuno-oncology and infectious disease research. As drug development for cancer and autoimmune diseases continue, there is a growing demand for specialized mouse models with human immune systems.
Germ-free mice are essential to microbiome research and the production of specific pathogen-free (SPF) rodent models. Research into the role of microbiota in health and disease has increased during the past decade due to the development of genetically engineered mutant animal models.
Transgenic mouse models are used for nearly every therapeutic and disease research area. Charles River delivers study-ready transgenic mice to meet your research needs.
Frequently Asked Questions (FAQs)
What is a mouse model?
Using mice as models of disease is done to understand specific biological phenomena and to provide insight into the workings of other organisms. By studying mice that have symptoms of diseases such as cancer, Parkinson’s, diabetes, or HIV, we can learn more about how these diseases might be treated in patients. As we improve the accuracy of modeling diseases in the mouse, we move closer to discovering cures in the clinic.
What are some of the advantages of mouse models?
Mice have many advantages over other animal models; to begin with, the mouse genome is similar to the human genome (99%). As with humans, mice have complex biological systems, such as the immune, endocrine, nervous, cardiovascular and skeletal systems; and naturally develop diseases that affect these systems, including cancer and diabetes. Mouse models have been successfully used to validate drug targets, and to determine efficacious and safe dosage levels for human and animal treatments.
Why are genetically modified mice used in research?
Genetically altered mice are rodents in which specific genes have been modified to create models of human and animal diseases. Depending on the complexity of the modification, it can be relatively easy to manipulate the mouse genome, by adding (knockin) or removing (knockout) a gene to better understand its role in the body. This offers an effective tool for modeling certain diseases when it is established that the mutated gene is known to play a role in the disease.