Oncology Pharmacology

Charles River has dedicated teams of oncology and immunology experts to design the best preclinical efficacy study for you. At the initiation of each study, a dedicated team is assigned to manage everything from design through execution. Our teams consist of scientists, technical personnel, a study director, and a project manager with each taking an active role to ensure seamless communication and flexibility for the duration of your study.

Human Translational Oncology Studies

Each study is designed to ensure the best version of your drug is progressed to the clinic. Many therapies fail later in the drug development pipeline due to lack of efficacy or proof of mechanism of action (MOA), and with increased focus on novel modalities, there are increasingly complex interactions with the patient and their immune system. Therefore, it is vital to test therapies as early as possible in models and assays that mirror the patient environment.

By choosing the most relevant models, it allows MOA to be established as early as possible, mitigating risk of progressing prematurely to the next stage, and allows continued monitoring of target engagement throughout the drug discovery process for more informed decisions.

For example, we can leverage many of our proprietary patient-derived xenograft (PDX) models and cell lines to perform integrated preclinical profiling of anticancer agents. Many of the models in our library correspond to established cell lines that have been derived from the xenograft model. This unique capability enables you to use the same tumor entity throughout your 2D in vitro, 3D ex vivo, and in vivo PDX assays. This approach to your program keeps efficiency and cost in mind, while letting you quickly collect the best study data. By using the same tumor model in your assays, we can leverage our extensive cancer model database, and offer insight and clinically relevant information throughout the life of your study.

End-to-end Oncology Studies

By working with Charles River throughout your drug development, we can help ensure your preclinical studies are designed optimally for faster entrance to the clinic:

Partner with a CRO who anticipates your needs with delivery of fast, flexible service and a proven ability to take therapies from discovery to market. We are true experts in oncology with over 20 years’ experience, allowing us to support drug discovery across the pipeline and across the full range of modalities and targets.