Contributors Michael Accardi, PhD Safety Pharmacology Toni Ahtoniemi CNS Drug Discovery Lloyd V. Allen, Jr. Editor-in-Chief, International Journal of Pharmaceutical Compounding Mark Anderson Scientific Manager, Department of In Vitro Sciences, Charles River Elizabeth Anderson, PhD Scientific Director Oncology, Early Discovery Clio Andreae Microbiologist, Global Discovery Services Alessia Arduin Senior Scientist Lucas Armstrong PhD Associate Director, Cell & Molecular Biology Anya Avrutskaya Client Services Manager Omar Aziz Director of Biology Julia Baker Veterinary Pathology Sheri Barnes Study Director, Discovery Research Services, Charles River Michael Barnes Senior Scientist, Integrated Biology Laurie-Anne Batraville QA Auditor 1 Andrew Baxter Director of Business Development, Early Discovery Damian Bell Principal Scientist, Biology Allyson J. Bennett Developmental Psychobiologist, University of Wisconsin-Madison Debadeep Bhattacharyya Thermo Fisher Scientific Lauren Black Senior Scientific Consultant, Charles River Denise Black Women’s Health Specialist, Dakota Medical Centre Deborah Blake Quality Assurance Auditor, Charles River Michael Bodnarchuk Molecular modeler, Discovery Research Services, Charles River Kimberly Brannen Principal Scientist, Merck Perla Breccia PhD Principal Scientist Jim Brockman Marilyn Brown Corporate Vice President, Global Animal Welfare, Charles River Cindy Buckmaster Center for Comparative Medicine, Baylor College of Medicine Steven J. Bulera Executive Director of GLBL Toxicology, Charles River Sarah Burnheimer Marketing Communications Coordinator Marloes Busschers Senior Regulatory Toxicologist Johnny Cardenas Marketing & Business Development, AB SCIEX Alison Carter Regulatory Affairs Specialist Laura Casey Senior Manager, Business Operations Lucia Ceresa Senior European Product Specialist, Microbial Solutions Simon Chapleo Functional Manager, Charles River Kathryn Chapman Executive Manager, Milner Therapeutics Consortium Robert Chapman Senior Scientist, Early Discovery John Ciallella, PhD Sr. Research Scientist, Toxicology Operations David Clark, PhD Computer-Aided Drug Design Charlie B. Clifford Veterinary Pathologist Kendyll Collins Education Interpreter III Cassidy Collins Technician II, Viral Clearance Group Margaret Collins Associate Director of Research, Charles River James Cooper, PharmD Consultant and Founder of Endosafe Inc. Christine Copeman Scientific Director, Infusion, Parenteral and Neurotoxicology, Charles River Joe Cornicelli Scientific Advisor, Discovery Research Services, Charles River Sophie Cotton Associate Scientific Director, Biomarkers Warren Crabb Staff Scientist, Accugenix Charlotte Cumper Infection Laboratory Scientist Kamil Czuchrowski Assistant Scientist, In Vitro Toxicology Philip Damiani Director of GEMS and Rederivation Operation, Research Models & Services Jamie Davies Professor of Experimental Anatmomy Kévin Dhondt Cheryl DiCarlo Research Models Services Rodney Dietert Professor of Immunotoxicology, Cornell University Niall Dinwoodie Biologics Site Lead John Dixon Director, JD International Consulting Ltd. Mustafa B. A. Djamgoz Imperial College Deborah Dormady Letham, PhD Biologic Methods Elizabeth Doughman Editor-in-Chief Christopher Dowdy, PhD Genetically Engineered Models Kevin Doyle Group Leader, Lead Optimization, Charles River John Dubczak General Manager, Microbial Solutions, Charles River James Duffy Associate Director, Drug Discovery, Medicines for Malaria Venture Elaine Duncan Assay Development, HTS Scientist Stephen K. Durham Retired Pharmaceutical Industry Executive Christoph Eberle Principal Scientist, Oncology Amy Eckert NewAgeSys Contractor Scientist, Janssen Aaron Edwards Mold Machine Technician William Esmieu Senior Scientist Ria Falvo, BSc, DABT Toxicology Christine Farrance, PhD Microbial Identification Laurie Fenton Ambrose President & CEO, Lung Cancer Alliance Steve Festin, PhD Director of Scientific and Commercial Development, RMS Services Lauren Foster Social Media Marketing/Advertising Strategist Joe Francisco Scientific Advisor, Business Development, Charles River Julie Frearson Senthil Gandi Senior Research Scientist, Charles River Russell Garland Principal Scientist Brianna Gaskill Animal Welfare Professor, Purdue University Peter Gaskin Senior Director of Scientific Advisory Services Jerry Gault Fisherman Fios Genomics Fios Genomics Nancy A. Gillett Retired Biomedical Executive James Gombold Site Director, Biologics Testing Solutions, Charles River Geoffrey G. Goodrich Senior Research Scientist, Charles River Martin Graf Research, In Vivo Oncology Jens-Peter Gregersen, DVM Biomedicines Consultant Dustin Grinnell Free-lance Writer Thomas Gruetzner Senior Research Scientist Robert E. Guldberg Professor of Bioengineering, Georgia Tech Ilse Haisma Group Leader, Early Discovery Michael Hantman Associate Director, Methods Development Gemma Hardman Senior Scientist, Integrated Biology David Harris Research Director Roger Hayes Senior Vice President & General Manager Ken Henderson, PhD Laboratory Animal Health Monitoring Ulrike Herbrand, PhD Bioassay Development Richard Hill Director of Business Development Alan Hoberman Global Director of DART and Juvenile Toxicology Robert Hodgson Director of Science, Research and Discovery Beth Hollister Student, Duke University Henry Holzgrefe Safety Pharmacology Consultant, Charles River Sunhee Hong Senior Staff Scientist, Accugenix, Charles River Rich Horgan Founder and President Noel Horton Principal Research Advisor, Tuulia Huhtala Head of Biomarkers and Molecular Imaging, CNS Discovery Sylvie Hunt Senior Immunologist, Cell Biology Mariangela Iovino Senior Scientist, Charles River Discovery Shawna Jackman, PhD Cell and Gene Therapy/Phototoxicity Rebecca Jarvis Medicinal Chemistry, Early Drug Discovery Rhiannon Jenkinson, PhD Discovery Immunology Mark Johnson Senior Director, Surgery Department Samantha Jorgensen Tyler Judd Animal Technician I, Insourcing Solutions Robert Kaiser Safety Pharmacology Regina Kelder Eureka Editor Rachael Kerr Senior Technical Writer, Microbial Solutions Prasanna Khot Research and Development Manager, Accugenix Sandy Kimber Senior Scientist/Manager Glenn E. Kirsch Retired Pharmacology Executive Axel Kornerup Hansen Laboratory Animal Science Professor, University of Copenhagen Ira Koval Section Head of Global Regulatory Consultancy Kritika Kumar Supervisor of Manufacturing Services Douglas B. Learn Director of Photobiology and Cellular Therapeutic Safety, Charles River Elise Lewis Director of Reproductive and Neurobehavioral Toxicology Ian Linney Group Leader, Early Discovery Don Liu Principal Research Scientist, Genetic Testing Services Chris Lock Senior Scientist, Medicinal Chemistry Richard Long Scientific Director, Charles River Pathology Associates Janet Lord Emanuele Loro Senior Scientist in Biology and High-Throughput Screening Elton Machholz Manager of Learning and Development, Charles River Vivek Mahajan Research Scientists 1, Discovery Research Services, Charles River Peter Mansell Associate Scientific Director, General Toxicology, Charles River Sara Marinelli Neuroscientist Elisa Masat Lab Immunologist, Discovery Mary Ellen Mateleska Director of Education and Conservation Kevin McCormack Sr, Director of Public Communications & Patient Advocate Outreach Karen McCullough Principal consultant Mary McElroy, PhD In Vivo Discovery/Cell Therapy Rona McGregor Study Director, Bioanalysis Team Fraser McIntosh In Vivo Pharmacology, Evotec Alice McVey North American Research Models and Services, Charles River Gary Merkel Software Applications Manager Paula Miliani de Marval Study Director, Charles River Discovery Hiroyuki Minami, PhD Discovery, Safety Assessment Japan Eric Minikel Prion Scientist Deidre Mitchell R&D Microbiology Manager Panagiota Momtsios Research Associate, Molecular Diagnostics John Montana Executive Director, Scientific Alliances, Charles River Samuel Mooney Senior Regulatory Affairs Specialist Mark A. Morse Director of Research, Charles River Iva Morse Corporate Vice President (CVP) & Chief Scientific Officer James Mui Senior Scientist, Medicine Chemistry Sydney Mukaratirwa Senior Veterinary Pathologist Guy B. Mulder, DVM Research Models Services, Biosecurity Joseph Murphy Cancer Immunology Ann Murray Director, Business Development Christopher Murriel Principal Scientific Advisor, Discovery Oncology Manasi Nandi Senior Lecturer, Integrative Pharmacology Matt Newby IT Principal Specialist Robert Nunan Senior Cell Biologist, Discovery Services Antti Nurmi, PhD CNS Drug Discovery Joan O'Malley Manager, Microbiology Department Carlos Obejero-Paz Principal Scientist, ChanTest Discovery Services, Charles River Marie Ojiambo Nastassja Ortega-Heinly, PhD Avian Services Matthew Paquette Product Specialist Madhav Paranjpe Senior Principal Pathologist, Mary Parker Host, Sounds of Science Barbara J. Patterson Corporate Vice President, Regulatory Affairs, Charles River Erin Patton Senior Product Specialist, Microbial Solutions Allesandro Pauletto Senior Account Manager Matthew Pennington, PhD Scientist, Virology Stephen Penrose Senior Scientist Carina Peritore Product Manager, Neuroscience Discovery Cheryl Perkins Scientist, Molecular Diagnostics Marie-Soleil Piche Scientific Director, Immunology, Charles River Jeff Plomley Senior Research Scientist, Algorithme Pharma Gerald Poeltl European Non-Pharma Sales Manager Florence Poitout Veterinary Clinical Pathologist, Scientific Director Kathleen R. Pritchett-Corning Senior Clinical Veterinarian, Harvard University Stuart Rankin Senior Scientist, Medicinal Chemistry Harun Rashid Principal Scientist Nick Ray Senior Director of Chemistry, Charles River Jean-Marc Raynard Technician Jessica Rayser Product Manager, Accugenix Elizabeth Reap Study Director, Oncology Timothy P. Reilly Executive Director, Immuno-Oncology, Bristol-Myers Squibb Amera Remick Executive Director of Pathology Justice Rickenbach Toni Roberts Rare Disease Survivor Laura Robinson Erik Rocheford Associate Director, Stratacuity: Proven Scientific Placement Teresa Romeo Luperchio Postdoctoral researcher, Johns Hopkins School of Medicine Clive Roper Head of In Vitro Sciences Clifford J. Rosen Senior Staff Scientist, Jackson Laboratory Daniel Rudmann Senior Veterinary Pathologist, Charles River Brian P. Ruvolo Director, Biosafety Testing Services Alicia Ryberg Senior Microbiology Technician Uma Saha Senior Manager, Embryology Rana Samadfam, PhD In Vivo Pharmacology Tim Sangster Bioanalysis and Immunology Department Head, Charles River Julia Schueler, DVM Discovery Oncology Jillian Scola Jillian Scola Louise Scott Report Complier II, Toxicology Administration Jezrom Self-Fordham Manager, Cell Biology William Shek Research Animal Diagnostics Hayden Skalski Technology & Marketing Development Manager Daniel Small Senior Specialist, In Vivo Discovery, Charles River Susan Y. Smith Former Senior Scientific Director, Charles River Eureka Staff Olaf Stamm Senior Business Development Specialist, Charles River Michael Staup Specialty Pathology Manager Eric Stitzlein Global Systems Program Specialist Scott Sutton Principal of Microbiology Network, Inc. Keith Sutton Scientific Advisor Carmen Sweeney Method Development Manager, Charles River Aidan Synnott Discovery Research Services, Charles River Kathleen Szabo Study Pathologist Yukihiro Takemoto Deanna Talerico Senior Director of Regulatory Compliance Stephen Tang President & CEO Rachel Tapp Senior Study Director, Neurobehavioral Sciences Michael Templin Senior Principal Scientific Advisor, Safety Assessment Brian Thill Director of Education Sebastian Tomlin Logistics Manager, Jeremy Turner, PhD Co-Founder & CSO, Turner Scientific Nikolay Turovets CEO, MediCell Technologies Marc Tye Zebrafish Core Facility Manager Sonia Vallabh Prion Scientist Aurore Varela Scientific Director of Musculoskeletal Research & Imaging Anjli Venkateswaran Senior Product Manager, Discovery Bindhu Verghese Senior Staff Scientist, Bacterial Taxonomy, Charles River Mark Vézina Scientific Director, Ocular and Neuroscience Department, Charles River Andy Vick Corporate Vice President, Safety Assessment Ohio Joanne Vinall Study Director, In Vitro Sciences Norman Wainwright Director of Research and Development, Microbial Solutions Audrey Walker Manager of Electronic Submissions, Charles River Rebecca Walker Comba Director of Toxicology, Charles River Emily Walsh Community Outreach Director Lyn Wancket Veterinary Pathologist II Chuanwu Wang Senior Scientist Stuart Ward Research Leader, Medicinal Chemistry Douglas Warner Functional Manager, Charles River Andrea Weir Senior Consultant, ToxStrategies, Inc. Jonathan Welch In Vitro Technologies, Genetic Toxicology Rhonda Wiler Senior Director, Transgenic Technology Department, Genentech Michele Wilkinson Director of Enrichment and Behavioral Medicine Anna Willox Senior Immunologist Stephen Wilson Study Director, Pharmacology, Charles River Christina Winnicker Institute of Comparative Medicine, Columbia University Jay Wortman Physician Kristina York Toxicologist, Charles River Giorgia Zaetta Medicinal Chemist Nina Zanella Head of Technical Operations and Facilities Danna Zeiger Biology Program Director, Fisher College Yan Zhi, PHD Director of Scientific Services Zachary Zimmermann, PhD Research Scientist, Neurobehavioral Sciences Aleksandra Zuraw, DVM, PhD Veterinary Pathology Anne-Marie Zuurmond Associate Director, Genome Engineering