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Targeting Histones With Modified CRISPR/Cas9

Rice University researchers have revealed a new epigenome editing technique, utilizing the ever-flexible CRISPR/Cas9 complex. Their version was designed to accurately target specific histones, which are basic proteins used to package DNA.

While most other CRSIPR/Cas9 tools can "cut" sequences in DNA, the Rice tool (which they call dCas9-dMSK1) can target without cutting. It uses the dMSK1 enzyme to phosphorylate the targeted histone, which can then turn on nearby genes.

While the technology is still a long way from being used in a therapeutic sense, the researchers say that it has confirmed how some histones communicate with each other. Read more at