Instituto de Salud Carlos III
Monday, April, 19 10h00 – 12h00
This event will be held on Microsoft Teams.
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10h00 Genetic Drift – What It is and How to Minimise its Impact on Your Research
The phenotypes of genetically modified mouse strains depend on the genetic mutation and background. Genetic background is subject to genetic drift which may result in phenotypic drift over time. In this seminar, you will learn about the following topics:
- The basis for genetic drift
- Case studies demonstrating genetic drift and its effects on experimental results
- The Jackson Laboratory’s unique Genetic Stability Program to stop cumulative genetic drift
- Steps to ensure the long-term genetic and phenotypic stability of your mutant mice
Speaker: Urte Jaeh, (Dipl. Biol.), EU Scientific Service Support Manager, Charles River
10h45 The Continuing Challenge of Genetic Background Stability in Mouse Research
Inbred mice have historically been essential models for scientific research, and will continue to be so. Indeed, genetic standardization plays a key role in reducing variances within study populations, it facilitates both the monitoring of therapeutic efficacy, and reduces differences between studies in order to maximize reproducibility of results.
However, recent studies have revealed that a high proportion of inbred mouse lines are genetically heterogenous populations. Genetic background pollution (even if subtle), absence of regular assessment and misinterpretation of genetic testing all lead to poor mouse model genetic standardization. This presentation will review:
- How genetic background heterogeneity may arise within a colony
- What molecular testing approaches such as polymorphic markers analysis (SNPs and STRs) really tell us about mouse genetics
- Best practices (colonies management and embryology tools) to put in place in order to keep control of the genetics of research mice
Speaker: Jean Cozzi, PhD, Innovation Manager, Genetically Engineered Models and Services Europe, Charles River
11h45 Questions & Answers
Carlos Garcia de la Torre
Business Development Manager
Phone: +34 616 526 178