Additional Specialised JAX™ Mice Now Available

Used by researchers around the world, JAX™ Mice are the most frequently cited strains in biomedical research publications and are supported by world-renowned scientific and technical staff. Through our exclusive agreement with the Jackson Laboratory, Charles River provides researchers in Europe and Asia with expedited access to over 9,000 JAX™ Mice strains and hundreds of new mouse models each year.

Starting in 2018, Charles River is now able to offer importation of several additional lines of JAX™ Mice suitable for a variety of research applications and therapeutic areas of interest including humanisation, immuno-oncology, immunology, and infectious disease studies. 

Further information including research application, genetic overview, phenotype, and more can be found on the website of the Jackson Laboratory by clicking on the links below for each model.

Full licensing requirement information is listed under the Terms of Use tab for each strain.

For more information, please contact our local customer service teams.

Short Name Full Nomenclature Overview JAX™ Stock Number

NSG-A2

NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Il2rgtm1Wjl/SzJ This humanized mutant strain combines the features of the NOD/ShiLt background, the severe combined immune deficiency mutation (scid), IL2receptor gamma chain deficiency and expresses human HLA-A2.1 MHC class I molecule. This model may be useful for studying response to human antigens, such as Epstein-Barr virus, possibly representing a unique preclinical model for vaccine development. 009617
NSG B2m NOD.Cg-B2mtm1Unc Prkdcscid Il2rgtm1Wjl/SzJ These NOD scid Il2rynull B2mnull triple mutant mice combine the features of the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency, and the MHC class I molecule (beta-2 microglobulin) deficiency and are relatively resistant to graft versus host disease (GVHD). They provide a model useful to study in vivo mechanisms of xenogeneic GVHD and to rapidly assess therapeutic agents. 010636
NSG-SGM3 NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ  The triple transgenic NSG-SGM3 (NSGS) mice expressing human IL3, GM-CSF and SCF combine the features of the highly immunodeficient NOD scid gamma (NSG) mouse with cytokines that support the stable engraftment of myeloid lineages and regulatory T cell populations. As a result, these NSG-SGM3 mice allow superior engraftment of diverse hematopoietic lineages and primary AML samples than other models and are useful for immuno-oncology, immunology and infectious disease studies. 013062
NSG-hHGFki NOD.Cg-Hgftm1.1(HGF)Aveo Prkdcscid Il2rgtm1Wjl/J NSG-hHGFki mice are NOD.scid.Il2Rγcnull ("NSG") animals with the Hgftm1.1(HGF)Aveo "humanized" knock-in allele (hHGFki). Homozygous NSG-hHGFki mice have no mature T cells or B cells, lack functional natural killer (NK) cells, are deficient in cytokine signaling, and express human hepatocyte growth factor (HGF) in place of the endogenous mouse HGF. These mice may be useful in studying the HGF/MET pathway in human tumor xenografts and mouse tumor allografts, as well as examining the ability of anti-HGF to inhibit angiogenesis and other tumor/stroma interactions. 014553
NRG-DRAG NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/ScasJ DRAG mice are NOD.Rag1KO.IL2RγcKO ("NRG") animals with chimeric human-mouse class II transgenes encoding the HLA class II antigen binding domain molecules (defined by the HLA-DR4 genotype [HLA-DRA/HLA-DRB1*0401]) fused to the I-Ed MHC class II molecule. The presence of these HLA-DR4-IE transgenes allows enhanced HLA-DR-matched hematopoietic stem cells (HSC) engraftment and subsequent human T cell and B cell development. Because the human HLA-DR4 genotype is associated with the development of autoimmune diseases (rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and lyme disease-induced arthritis), these DRAG mice may be useful as an in vivomodel for studying human T cell/B cell development and function, vaccine testing, and generation of "fully human" IgM, IgG, IgA or IgE monoclonal antibodies for prophylactic and/or therapeutic use in autoimmune diseases and infectious diseases. 017914
NSG-(KbDb)null NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe Il2rgtm1Wjl/SzJ NSG-(KbDb)null mice are NOD.scid.Il2Rγcnull ("NSG") animals with knockout alleles of the MHC class I genes (Kb null and Db null). Homozygous NSG-(KbDb)null mice lack murine major histocompatibility complex (MHC) class I and exhibit reduced xenogeneic graft-versus-host disease response (xeno-GVHD) following human peripheral blood mononuclear cells (PBMC) engraftment. These mice may be useful for transplantation studies to investigate the role of MHC class I and central and peripheral tolerance in the xeno-GVHD. 023848
NRG-SGM3 NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/J NRGS (NRG-SGM3) mice are NOD.Rag1-/-;γcnull (NRG) animals expressing human interleukin-3 (IL-3), human granulocyte/macrophage-stimulating factor (GM-CSF) and human Steel factor (SF) from the SGM3 (3GS) triple coinjected transgenes. NRGS mice may be useful for cell or tissue transplantation studies on a background expressing human cytokines, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host. 024099
Triple KO (TKO) B6.129S-Rag2tm1Fwa Cd47tm1Fpl Il2rgtm1Wjl/J Triple Knockout mice lack RAG2, CD47, and X-linked IL2RG making them tolerant of xenotransplantation, resistant to graft versus host disease, and susceptible to HIV. 025730
NSG-Hprtnull NOD.Cg-Prkdcscid Hprtem1Mvw Il2rgtm1Wjl/MvwJ NSG-Hprtnull mice are NOD.scid.Il2Rγcnull ("NSG") animals with the Hprtnullknockout allele. The NSG model is permissive for xenograft/human tumor growth, with Hprt-deficiency allowing human tumors to be transplanted into culture and any mouse cells removed (via HAT selection). 026222
NBSGW NOD.Cg-KitW-41J Tyr + Prkdcscid Il2rgtm1Wjl/ThomJ These NBSGW mice support engraftment of human hematopoietic stem cells without irradiation. They are suitable for use in applications related to xenotransplantation. 026622
NSG-HLA-DQ8 NOD.Cg-Prkdcscid H2-Ab1tm1Gru Il2rgtm1Wjl Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ NSG-HLA-DQ8 mice lack murine MHC class II and express mutant human leukocyte antigen (HLA)-DQ8 on the immunodeficient NOD scid gamma (NSG) background. This strain may be useful in studies utilizing an autoantigen-specific vaccination approach for the prevention of islet autoimmunity in individuals susceptible to type I diabetes. 026561
NSG.PDL1- NOD.Cg-Prkdcscid Cd274tm1Shr Il2rgtm1Wjl/J PDL1-/-.NOD NSG mice are NOD/LtJ-congenic animals carrying the PD-L1- (Cd274-) knockout mutation that have been backcrossed to NSG mice. 027905
NSG-PiZ NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(SERPINA1*E342K)#Slcw/SzJ  NSG-PiZ mice express mutant human SERPINA1 (Glu342Lys mutation) on the immunodeficient NOD scid gamma (NSG) background, providing a stable engraftment environment for primary human hepatocytes after partial hepatectomy. This strain may be useful in studies utilizing a humanized liver xenograft mouse model. 028842