Charles River Offers Embryology Services & Contract Breeding
of Genetically Engineered Mice and Rats
Model Evaluation Program
Do you wish to trial a model to test suitability before making a purchase? Explore our free animal model evaluation program.
Trial a Model
If you need a highly immunodeficient mouse model...
Our NCG mouse model is the most highly immunodeficient mouse and the model of choice for cancer xenograft modelling, stem cell biology, humanized mice, and infectious disease research.
Academic Welcome Program
Our Academic Welcome Program is designed to provide new, inquiring researchers with special discounts and technical support for their next study. These offers are valid through December 31, 2021.
Johns Hopkins receives preferential pricing and unique offers for many of our products and services, including:
• 20% Off Mouse Research Models
• 35% Off C57BL/6 Mice
• 20% Off Triple-Immunodeficient NCG Mice and RNU Aythmic Rats*
• $37.86 Ahtymic Nude, NU/NU and Nu/NU CD1 Mice**
• $43.26 SHO (SCID Hairless Outbred) Mice**
* Plus free shipping
**Flat rate for all ages and any sex
Our NCI 2021 catalog offers grantees a reduced price on popular models. Pricing for NCI grantees will not increase in 2021.
Download our catalog using your JHU email account to view research model discounts and terms and conditions for Johns Hopkins University. If you have additional questions, contact Jennifer Marion for more information.
Immunodeficient models are important for a variety of research applications. The chart below, showing immunodeficiency and phenotypes, can be used to help identify the model that best fits your research needs. Johns Hopkins receives preferential pricing on many of our immunodeficient models.
|SCID Hairless Congenic (SHC™)||Mouse||YES||YES||NO||NO|
|SCID Hairless Outbred (SHO®)||Mouse||YES||YES||NO||NO|
|Fox Chase SCID®||Mouse||YES||YES||NO||YES|
|NCI NOD SCID® Beige||Mouse||YES||YES||NO||YES|
|Fox Chase SCID® Beige||Mouse||YES||YES||Impaired||YES|
• CD34+ Humanized Mouse Model
Our xenograft data collection is designed to help you decide the most appropriate animal model to use when designing a study. To assist you in expediting your model selection process, we have compiled xenograft data on the following models.
|Charles River Oncology Resources
• Immunodeficient Models Xenograft Data Collection
• Immunodeficient Mice
• Humanized Mice
• Tumor Model Compendium
|Non-GLP Cell Line Testing
• Research biologics of rodent or human origin are often introduced into research animals as part of an investigative procedure. Screening should be performed to confirm that biologics are free of infectious agents and that they originate from the specified host species.
• Our 2021 Welcome Program offers new customers a 50% discount for cell line screening through March 31. Contact us for more information.
• Jugular vein catheterization benefits preclinical or research studies because it allows for easy and/or repeated intravenous access without the need for anesthesia. This surgical service can be used for manual dosing and/or sampling as a means for long-term infusion using automated equipment.
Ask about our bundled offers for Oncology Models and Services.
|Genetically Engineered Models and Services (GEMS)
Our GEMS division offers a wide variety of services from breeding to model creation. Our decades of experience and vast network of vivariums around the world gives us the opportunity to offer an unparalleled selection of custom models and services to meet your unique needs. Researchers at Johns Hopkins receive many discounts off services provided by GEMS. Use our quoting tool to view the best price for your study.
|Model Creation Services
Our experts can guide you through the model creation process.
No need to worry about breeding your own colony – we’ll deliver animals to you when you need them.
Our embryology services will help you protect your lines and generate new ones.
• Our cryopreservation services can protect your lines from genetic drift, natural disasters, and catastrophic events.
• Rederivation can help you obtain animals that are free of infectious agents.
• Rapid colony development uses sophisticated IVF technology to generate animal colonies quickly.
Our isolator-based quarantine is ideal for accepting animals into any institution.
We offer assay development and genotyping services to maintain the integrity of your lines transgenic lines.
|Non-GLP Cell Line Testing
Research biologics of rodent or human origin are often introduced into research animals as part of an investigative procedure. Screening should be performed to confirm that biologics are free of infectious agents and that they originate from the specified host species.
Our surgical services are conducted by highly skilled surgeons with vast experience in veterinary medicine and animal science with the ability to perform highly complex catheterizations and cannulations. Our services include:
• Vascular catheterization
• Non-vascular catheterizations
• Cardiovascular surgery
• Neurological procedures
• Soft-tissue Procedures
• Device implants
|Johns Hopkins University Virtual Seminars
Immunodeficient and Humanized Models: Applications for Immuno-Oncology Research – Passcode: K6S$qqB!
Check out our free, digital laboratory animal guidebooks on infection surveillance of rodents and colony management for mice and rats.
• Modern Strategies for Infection Surveillance
• Mouse and Rat Colony Management
• Targeting the Human MUC1-C Oncoprotein with an Antibody-Drug Conjugate
JCI Insight, 2018)
• Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice
Molecular Therapy – Methods & Clinical Development, 2017)
• Accumulation of Cytoplasmic CDC25A in Cutaneous Squamous Cell Carcinoma Leads to a Dependency on CDC25A for Cancer Cell Survival and Tumor Growth
(Cancer Letters, 2017)
• On demand
• GEMS webinars, covering cryopreservation to CRISPR/Cas9 model creation
• Germ-Free Colony Management
• Maintaining a Static Microbiome Across Research Projects: Can It Be Done?
• Continuous Improvements in Humanized Mouse Models
• Finding the Right Humanized Model for Your Research
|Seminar Topics (Personalized Trainings)
Our team of Research Model Specialists offer free educational seminars on a variety of topics, including:
• Immunodeficient and humanized animal models for oncology studies
• Using and applying our vascular catheter models
• Others, upon request
• Common Rodent Health Conditions
• Metabolic Diseases
• Immunodeficient Mice
• Jugular Vein Catheterization
• Surgery Model Utilization in Oncology
|Regulatory Training and Continuing Professional Development
Charles River Insourcing Solutions℠ provides high-quality training and continuing professional development for veterinarians, scientists, lab technicians, and anyone else working in the field of animal research. Courses for rodents, zebrafish, and other species include personal license holder categories PIL A, B & C, and a PPL Module for project license applicants. CPD courses include NACWO, NTCO, a law refresher course, and more.
In person and eLearning options are both available. See our upcoming courses at a location near you, or contact Jennifer Marion about delivering a course at your facility.
Read more on ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments), which include clear guidance on research model nomenclature guidelines and other reporting criteria.
|How can I get information about special offers on research model and services?
Please contact Johns Hopkins University's Senior Business Development Director [email protected] or call/text 610-324-9468.
|What is your evaluation program?
Our evaluation program offers free research models to clients that have not used a strain to evaluate the quality and compatibility of our animal models with their research before making a commitment. Whether you have a new research protocol, are conducting or fine-tuning a pilot study, or simply exploring the opportunity to switch to a new animal model, this program can help you make the right choice.
|Do you have any COVID-19 related resources?
Yes. Take a look at our COVID-19 resources. A popular model for work on SARS-CoV-2 is Syrian Hamsters.
|Do you have aged C57BL/6 mice?
Yes. We have an aged C57BL/6 colony.
|Are health reports available?
Yes. Health reports are available for research animal models bred by Charles River in North America.
|Where can I find additional educational resources?
See our expanded digital resources.
|Do you provide information on infectious agents?
Yes. Understanding infectious agents that can contaminate your research animal facility allows you to develop a plan to manage or prevent an outbreak. Our technical sheets contain information on viruses, bacteria/fungi, and parasites prevalent in laboratory animals.
|When can I expect delivery?
Delivery day for Johns Hopkins University is Tuesday.
|How do I contact Charles River?
Please contact our US client services team directly:
• Email: [email protected]
• Phone: 1-800-522-7287