Charles River Immunology Services Portal

We are committed to providing pharmaceutical and biotechnology companies solutions for the discovery and development of new medicines. In 2019, we supported the development of approximately 85% of the drugs approved by the FDA. Advances in immunology research have clarified the role the immune system plays in many different disease areas, even those that have not been traditionally thought of as having an immune component.

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We have gathered information about all of the relevant Charles River immunology services available to you along with special offers, resources, and contact details.

WE CAN CREATE CUSTOM TRANSGENIC MOUSE & RAT MODELS

We help clients select, customize, create, and maintain the right models for their studies using the latest technologies. Our expert staff can work with you from concept to model creation to deliver the research animals you require.

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WE CAN HELP YOU GET VACCINES TO MARKET

With decades of experience supporting the vaccine industry, our global network of scientific and regulatory experts provides vaccine developers with the right expertise early in the development process to boost productivity, efficiency, and profitability, and to help you get the safest and most effective vaccines to market.

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three mice

 

RISK IN PRECLINICAL CANDIDATES CAN BE REDUCED WITH PREDICTIVE IMMUNOTOXICOLOGY

Due to the intrinsic complexity of the predictive immunotoxicology assessments, definite designs are not rigidly specified. This whitepaper will help you to drive your program through this requirement and challenges in delivering an appropriate set of assessments for regulatory review.

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WE OFFER CONTRACT BREEDING OF GENETICALLY ENGINEERED MICE AND RATS

We provide a full-service rodent colony management program to deliver transgenic animals to you when you need them, in the exact quantities you specify, and with the health status that you require.

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WE PROVIDE CUSTOMIZED WORKPLACE SOLUTIONS

Offering staffing, training, consulting and other animal facility support services, we can help you streamline your drug discovery and development programs and make best use of your resources and achieve optimum results.

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Animal models, translational immunology assays, autoimmune and inflammation models that accurately reflect the human immune system are powerful tools to advance your immunology research. 

Animal Models for Disease Studies
Charles River maintains a comprehensive portfolio of animal models specific for studying diseases. Further, through our preconditioning services, we can offer an array of surgical procedures, so that you receive your animal study ready.

Find a model

Evaluate a model at no cost via our Animal Model Evaluation Program.
Immunology and Inflammation Models
Charles River's expert immunologists and microbiologists can support your immunology programs with a wide selection of in vivo and in vitro immunology assays, immuno-oncology assays, inflammation, autoimmune and infection models, across numerous therapeutic areas, including vaccine development, infectious disease, immuno-oncology, neuro-inflammation and fibrosis.
 
 
Take deep dive into our in vitro assays and in vivo models.

 

Highly Immunodeficient Models
Animal Models can contribute invaluable information to the discovery and development of new drug. Besides standard strains such as C57BL/6, BALB/c or CD-1, Charles River exclusively offers the most immunodeficient NSG® with possibilities for humanization
Requirements for Immunology Safety Assessments
Assessment of immune endpoints will be required for any therapeutic which is either designed to modulate immune function or belongs to a class of compounds with known immunomodulatory potential. The ICH S8 & ICH S6(R1) guideline for human pharmaceuticals with immunomodulatory actions recommends a weight-of-evidence approach to assess potential immunotoxicity risk. Additional immunotoxicity endpoints reflecting the mechanism of action of the compound should be included within study designs, as immunophenotyping, cytokine measurements, in vitro immunology testing, TDAR assay or Immunogenicity assessment.

At Charles River, you'll find a dedicated multidisciplinary team of global immunologists, statisticians and drug development experts who can help you devise the best strategy for your therapeutic so you can move forward to IND and monitor your drug in clinic.
Pharmacodynamic Biomarkers
Incorporating proof of mechanism endpoints into early clinical trials, which are traditionally run only for safety endpoints, means pharmacodynamic (PD) biomarker assays can confirm target engagement in first in human studies, improving your chances of moving to Phase III. Charles River can customize PD biomarker assays to support go/no-go decisions for your program.
Clinical Research
In the clinical phase, immunology assays become critical for almost all advanced therapeutics – from small molecules, monoclonal antibodies (mAbs) for oncology, through vaccine programs, microbiome, as well as gene and cell therapies. Clinical immunological assays will be required for any therapeutic that might trigger an immune response to ensure the response doesn’t compromise patient safety.

Our expertise can help you choose the right tools to analyze samples from multicenter clinical trials.