Progress the best version of your therapy with actionable data from the latest advances in oncology research. Our world-class team of oncology and immuno-oncology experts are proud to offer these tools to support your program.
In vivo microdialysis services for sampling the tumor microenvironment
Monitoring changes in the biochemistry of tumors is essential to our understanding of cancer biology and our ability to develop novel cancer therapies. Microdialysis is a uniquely sensitive, powerful method of sampling the tumor microenvironment in murine models. With it, we can detect and quantify multiple immunomodulators and oncometabolites, elucidating mechanism of action. The actionable data delivered by microdialysis informs decision making and supports faster progress to the clinic.
Learn more about how our microdialysis services can help with your program.
GvHD and other screening models
Our oncology discovery team has two new Graft Vs Host Disease (GvHD) mouse study models that can be used to evaluate treatments for this common complication of HSCT (hematopoetic stem cell transplantation) treatment, or as a screening platform to test mechanisms of immunoregulation.
Pharmacodynamic screening models such as our GvHD model can provide valuable early information to aid decision making. Other screening models offered by Charles River include our Adoptive T Cell Transfer model, watch this video to learn more.
CAR T cell and cell therapy testing services
A powerful branch of oncology therapies, CAR-T development differs from traditional drugs. With comprehensive support for the development of CAR-Ts and other cellular therapies, we can help you accelerate your program. Learn how to meet the challenges of this promising therapy in our webinar, How to Design & Execute Successful CAR T Cell Therapy Programs (available through The Source℠). Want more information? Listen to our podcast or watch this video, In vitro cytotoxicity testing of CAR T Cells.