Featured Story

Are Your Products Free of Coronavirus?

coronavirus

Before COVID-19, manufacturers across biotech, medical devices, textiles, and more were concerned with viral contamination in their products. In response to the new threat SARS-CoV-2 poses to drug, personal product, and equipment safety, our team of experts has developed and validated two new models to support SARS-CoV-2 viral clearance evaluations.

From testing of manufactured products to efficacy studies for SARS-CoV-2 therapeutics, we offer several robust validated models for viral contamination and clearance testing suitable for biosafety level 2 (BSL-2) facilities:

Connect with an Expert

As a highly infectious airborne agent, live SARS-CoV-2 must be handled in a BSL-3 facility; at present, these facilities are more commonly available to medical and academic researchers. Plans to establish our own BSL-3 are underway, and scheduled to come online Q1, 2021, as Charles River continues to enhance support for coronavirus-focused drug development.

Virus
Virus Family
Virus Genus
Envelope
Genome Type
Genome Size [kb]
Particle Size [nm]
SARS-Cov-2 
Coronaviridae
Betacoronavirus (sub genus: Sarbecovirus) 
Yes
(+) ssRNA 
29.8 – 29.9  
80 – 170* 
Porcine hemagglutinating encephalomyelitis virus (PHEV) 
Coronaviridae
Betacoronavirus (sub genus: Embecovirus) 
Yes
(+) ssRNA 
29.9 –30.0 
110 – 130 
Human coronavirus, strain 229E 
Coronaviridae
Alphacoronavirus (subgenus: Duvinacovirus) 
Yes
(+) ssRNA 
28.5 
100 – 150 
Parainfluenza virus Type 3 (PI-3)
Paramyxoviridae
Respirovirus
Yes
(-) ssRNA 
13.0 – 18.0 (15) 
150 – 250 
* mean 120 – 130 including peplomers (based on Robert Koch Institute, electron microscope diagnostics)