Biodistribution and Immune Complex Assays
Want to know whether your biologic therapy is crossing the blood-brain barrier or infiltrating your target organ? Test article biodistribution and immune complement (TABD-IC) assays employ a specialized panel of detection agents to determine where in the body your biotherapeutic or endogenous animal immunoglobulins are distributing. This immunohistochemistry (IHC) pathology technique is typically performed during safety assessment or pharmacodynamic/pharmacokinetic studies. A highly versatile pathology technique, IHC is a valuable tool for localizing a test article in animal tissues.
With biologics and biotherapeutics, biodistribution can be compared with the endogenous immunoglobulin pool in the animal species. In addition, when working with biotherapeutics such as monoclonal antibodies in toxicologic animal species, immunogenicity is often observed that can lead to immune complex (IC)-related pathologic changes, including infusion reactions and other IC-related pathologies. Such unexpected immune related effects of biologics and biotherapeutics can be better assessed with an IHC immune complex (TABD-IC) assay that detects both drug and anti-drug antibodies and complement activation within tissues.