three healthy mice

Changes to Charles River Europe's Health Reports

Murine Chapparvovirus (MuCPV)

From March 2021, Murine Chapparvovirus (MuCPV), also known as Mouse Kidney Parvovirus (MKPV), has been added to our health monitoring reports for Charles River SPF/VAF Plus® and SOPF/VAF Elite® mice. Please note that the official name Murine Chapparvovirus has been provisionally given by the International Committee on Taxonomy of Viruses (ICTV).

MuCPV infection results in intranuclear inclusion bodies in renal tubular epithelial cells with variable incidence based on immune status. Intranuclear inclusion bodies of mouse renal tubular epithelium (inclusion body nephropathy, IBN) have been anecdotally observed by veterinary pathologists for more than 40 years.

In 2018, the journal Cell reported that Roediger et al. confirmed the causative agent. Since then, sensitive and specific PCR tests and serology have become commercially available for diagnostic purposes.

Infectious Agent Naming Changes

The International Committee on Systematics for Prokaryotes (ICSP) has recently assigned new names to the following agents:

Parasite Disclosure by Genus and Species

In response to client feedback regarding a comprehensive disclosure of parasites by genus and species, we have expanded our list to include (genus and/or species) common pathogens and select opportunistic protozoa.

If you have further questions, please reach out to your respective Charles River customer service department, account manager, or veterinary team.