Crown Bioscience has granted an exclusive license to Charles River to breed and distribute CrownBio's ZDSD (Zucker Diabetic Sprague-Dawley) rat.
The ZDSD rat is a highly translatable rodent model of metabolic syndrome, obesity, dyslipidemia, and diabetes with complications such as cardiac dysfunction, proteinuria, and impaired wound healing. It has a polygenic background and intact leptin pathway. The ZDSD rat more closely mimics human disease development.
The model was developed by crossing the ZDF rat (Lean +/+) with the CD (SD) rat and selectively inbreeding for obesity and diabetes traits for more than 35 generations. The ZDSD does not rely on monogenic leptin or leptin receptor mutations for development of obesity and Type 2 diabetes and has been characterized as a novel model of diabetic nephropathy.
Multiple Models for Obesity Studies
The addition of the ZDSD model expands the Charles River portfolio of rat models developed for use in studies of Type 2 diabetes, hyperlipidemia, hyperinsulinemia, hypertension, glucose intolerance, metabolic syndrome, obesity, and genetic obesity. Charles River also breeds the Zucker rat, the ZDF (Zucker diabetic fatty) rat model, and the ZSF1 rat.