Developing Translational Biologics for Brain Disorders
To put it simply, neurological diseases are challenging. The mechanisms of brain diseases are highly complex and intertwined with mechanisms of aging, genetics and environmental factors.
Alzheimer’s presents one of the starkest examples of this. Its complexity has thus far prevented researchers from developing an effective therapy that can slow or stop the progression of symptoms or prevent the disease from occurring. It is a neurological disorder filled with unknowns. We do not know, for example, what the relationship is between the hallmarks of Alzheimer’s, including brain atrophy and over-expression of amyloid plaques, and the cognitive decline that occurs in people with this devastating condition.