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Modulating Immune Responses in Oncology

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Drug Discovery World

To effectively modulate the immune system and drive the regression of tumours, studies focus on multiple mechanisms to either slow cancer cell immune evasion or accelerate the stimulation of an immune response. These strategies include neutralising tumour-promoting inflammation (e.g., PD-1 and CTLA-4), broadening T cell repertoires via vaccination or CAR-T and elucidating the mechanisms by which immune cells organise tumour microenvironments to regulate T-cell activity (i.e., the role of myeloid derived suppressor cells, etc).

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