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A New Way to Target GPCRs

G-protein-coupled receptors (GPCRs) are a large, diverse group of cell surface receptors that hold promise in the development of therapies against diabetes, obesity, and Alzheimer’s disease. They are a class of cell surface proteins that are difficult to work with due their delicate, complex biological construction. Their cell surface is a seven-ply structure, responsible for complicated human functions such as touch, smell, and taste.

“GPCRs are beautiful but complex. They are woven seven times, back and forth through the membrane of the cell, like stitching a button,” said Sawsan Youssef, Senior Director of Immunology and Immuno-oncology at Distributed Bio. “Like a stitched button, when the thread is pulled out of the cloth, everything falls apart.” Oftentimes, as researchers are working with them, they tend to unravel, destroying the ability to raise antibodies against them.

Now, a new antibody discovery platform is available, giving drug hunters a means of keeping the membrane structure intact. The platform consists of the Superhuman antibody screening library and a proprietary technique to identify, isolate, and synthesize against GPCRs. It has been successful finding multiple functionally active, fully human anti-GPCR antibodies against CXCR5. The platform is available from Charles River through a partnership with Distributed Bio. To learn more, request a consultation with one of our discovery specialists.