Robust Method (Re)development Support
Residue analysis of agrochemicals and veterinary drugs in food products is a critical step to meet the stringent regulations for ensuring customer safety. A robust and precise method is a key point for further validation and sample analysis studies. Poorly developed methods could lead to severe consequences, including study delay, gaps in dossier submissions, or delay in product approval.
You may require method development studies for numerous circumstances. Perhaps you don’t have in-house methodology for the analysis of small molecules; alternatively, maybe your older analytical methods are no longer suitable or are now inappropriate. A lack of available resources, including the instrumentation, often drives the need to outsource such studies. Occasionally, older methods also need to be updated to meet new guidance requirements or include addition of new significant metabolites.
In our commitment to continued investment, our facility in Edinburgh has recently purchased new equipment to aid in the analysis of difficult compounds, e.g., the analysis of chiral molecules in complex matrices. For these studies, we may utilize the QTRAP 6500+ mass spectrometer combined with differential ion mobility technology (SelexION®+). This equipment is designed for rapid detection of ultra-low quantities of molecules in variety of samples.
Method Development Expertise
Method development can be a difficult, time-consuming, complex and expensive process. Our dedicated method development scientists have more than 10 years of hands-on experience working with method development for small molecules in a variety of sample matrices.
We develop analytical methods for the following analysis:
- Crop and animal residue studies
- Field soil dissipation studies
- Non-radiolabelled environmental fate studies
Our team is skilled in the many facets of method development, including but not limited to:
- Sample extraction
- Sample clean-up (SPE, d-SPE, QuEChERS, SelexION®)
- Chromatography (HILIC, Reverse Phase, Normal Phase)
- Derivatization of challenging compounds
- Analytical determination (LC-MS/MS, GC-MS, GC-MS/MS)
We develop our methods using state of art equipment such as Geno/Grinders (automated tissue homogenizers) or Turbo Vaps (automated solvent evaporation systems) which reduce sample preparation time, sample preparation errors, and improve method robustness and precision. During the process of method development, we collaborate with study directors who will perform the method validation to ensure that the developed methods will be fit for purpose. We also provide support to our validation team ensuring that the transfer of the developed method is achieved in the most time- and cost-efficient way. Every scientific issue encountered post-development can be quickly resolved by our dedicated method development team.