Translational Platform for Immuno-Oncology Discovery

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Image of cancer cells under a microscope.

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Immuno-oncology is a rapidly growing therapeutic field that embraces the concept of modulating the immune system to recognize tumor cells and target them for destruction—by either harnessing the effects of the immune system or preventing the evasion of tumor cells from therapeutic targeting.

The cancer immunity cycle consists of a complex interplay between tumors and immune cells that culminates in an immune response that kills cancererous cells (Figure 1).1 Tumors can prevent this interplay if they maintain a suppressive microenvironment. This microenvironment can also thwart anticancer drugs.2 Consequently, overcoming or remodeling the immunosuppressive microenvironment that is found in many solid tumors is a significant task.

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