代替ヘルスモニタリングプログラム
動物研究施設は、実験動物の使用を減らし、病原体サーベイランスを改善ために、センチネルフリーシステムに移行しつつあります。排気ダスト（EAD®）や環境PCR試験など、より高感度な方法を使って、動物の代わりに自然環境からサンプルをスクリーニングすることで、センチネル動物を使う必要性を減らしたり排除したりすることができます。さらに、この方法により、特定のげっ歯類の感染病原体検出のための既知の 不衛生な床敷センチネル法の限界も克服できます。 Charles Riverでは、施設に合ったプログラムをお客様と協力して開発しております。
ケージの種類別のサンプルプログラム
以下は、飼育設備で使用される動物飼育システムの種類に基づいた、さまざまな代替ヘルスモニタリング（HM）試験オプションです。
個別換気ケージ（IVC）
ほとんどの研究施設では、IVCを使用して動物モデルを収容しています。IVCラックの各ケージが独立した生物排除システムとして機能するため、さまざまな健康状態の動物を同じラックに収容できます。Charles Riverでは、IVC収容の動物モデル向けに、センチネルフリーおよびハイブリッドプログラムの両方をお届けしています。
サンプル採取ユニット
Get Quick Insights in Animal Health, On Your Schedule
Our Fast Tracks learning series offers short, on-demand presentations on how to protect the health and security of your animal models. It's fast and it's free.
Sentinel-free health monitoring is just one of the many topics covered as part of our Fast Tracks event. This series of short, on-demand presentations across six different tracks, including health monitoring, offers vital information to help you better protect the health and security of your animal models.
Sentinel-Free Sample Collection Method Examples
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Tecniplast Interceptor
Designed for Tecniplast caging systems, the Interceptor offers a more accurate and sensitive environmental health monitoring alternative to the soiled-bedding method by gathering samples via EAD® and using PCR to analyze them.
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Allentown Sentinel™ EAD®
Co-developed with Allentown, the Allentown Sentinel™ EAD® capture unit reduces the labor and time associated with manually swabbing a rack for samples. By placing the unit in the exhaust plenum of an Allentown rack, Sentinel™ EAD® automatically captures exhaust air dust samples as the air flows over its proprietary media. When it is time to test your rack (every three months), you can remove the integrated collection media and send it to Charles River for testing.
An Easier Way to Submit Your Samples
Our Laboratory Testing Management® (LTM™) platform can help streamline sample submission, result reporting, and tracking – all from one convenient place.
Frequently Asked Questions (FAQs) About Sentinel-Free Health Monitoring
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What cage types are used for sentinel-free health monitoring?
Two cage types are used for sentinel-free health monitoring:
Microisolator Cages
Microisolator (static) cages are a simple, yet effective design that enables a cage-level barrier between the inside of the cage and the external environment. This is established by utilizing a cage lid that has been fitted with a specialized filter that allows air flow but prevents environmental contaminants from entering the cages. Microisolators cannot use EAD® because there is no active air movement.Conventional Cages
Conventional (open-top) cages are absent of a filter top and are placed directly onto a rack or shelf. The main difference with this type of caging is that there is no barrier or protection between the interior of the cage and the room environment, therefore posing a higher risk to biosecurity. -
Which rodent health monitoring services are used to monitor the health of my research?
Diagnostic services to monitor the health of your animal colonies include: