実験 動物への 連続投与用輸液ポンプ
ALZET® 浸透圧ポンプには、注射や経口強制飼養による動物の反復投与に比べて、次のような特定の利点があります。
- 連続投与、極端な変動を排除
- 試薬の効果を完全に行き渡らせ、簡単に再現できます。これは、半減期が短い薬物で特に便利です。
- 頻繁な取り扱いから生じる動物のストレスの軽減
投薬には注射が最適ですか？
Charles River のホワイトペーパー「輸液 vs 注射:前臨床研究領域における医薬品化合物の投与に関する考慮事項」をダウンロードして調べてみましょう。
Charles River はオーストリア、ベルギー、チェコ共和国、フランス、ドイツ、ハンガリー、アイルランド、イタリア、ルクセンブルク、オランダ、ポルトガル、スペイン、スイス、英国における ALZET® 浸透圧ポンプの独占販売代理店です。
北米とヨーロッパで Charles River は、手術サービスの一環として、ALZET® 浸透圧ポンプおよび他の テレメトリー装置 を移植しています。
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ALZET® Osmotic Pump Details by Study Design
There are 12 models of ALZET® Osmotic Pumps in 3 physical sizes, and a variety of release rates and durations.* Dosage variability can be achieved by modifying agent concentration; duration can be extended by serial implantation of the pumps.
Pump Model
Volume
Duration
Release Rate
1003D
100 µl
3 days
1.0 µl/hr
1007D
100 µl
1 week
0.5 µl/hr
1002
100 µl
2 weeks
0.25 µl/hr
1004
100 µl
4 weeks
0.11 µl/hr
2001D
200 µl
1 day
8.0 µl/hr
2001
200 µl
1 week
1.0 µl/hr
2002
200 µl
2 weeks
0.5 µl/hr
2004
200 µl
4 weeks
0.25 µl/hr
2006
200 µl
6 weeks
0.15 µl/hr
2ML1
2 ml
1 week
10 µl/hr
2ML2
2 ml
2 weeks
5.0 µl/hr
2ML4
2 ml
4 weeks
2.5 µl/hr
* Lot Specific Performance Data: The nominal performance is a target for all pumps manufactured. Individual lots of pumps may vary from this target within limits. The actual pumping rate and fill volume of a particular lot (derived by statistical testing) are listed on the top of the instruction sheet included with the pumps.
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ALZET® Osmotic Pump Details by Animal & Delivery Method
The minimum animal size estimates for Implantation of ALZET® Osmotic Pumps are based on experience with male Sprague Dawley rats and Swiss Webster mice. When using the pumps with other strains or genders, these guidelines should be modified accordingly.
Pump Model
Mice SC
Mice IP
Rats SC
Rats IP
1003D
10 g
20 g
10 g
20 g
1007D
10 g
20 g
10 g
20 g
1002
10 g
20 g
10 g
20 g
1004
10 g
20 g
10 g
20 g
2001D
10 g
20 g
10 g
20 g
2001
10 g
20 g
10 g
20 g
2002
20 g
N/A
20 g
150 g
2004
20 g
N/A
20 g
150 g
2006
20 g
N/A
20 g
150 g
2ML1
N/A
N/A
150 g
300 g
2ML2
N/A
N/A
150 g
300 g
2ML4
N/A
N/A
150 g
300 g
SC = subcutaneous; IP = intraperitoneal
ALZET® Video Resources
Watch the above overview video to learn more about the technology, benefits, and applications of ALZET® Osmotic Pumps.
Further videos, including one that describes surgical implantation techniques, can be accessed through our secure portal, The Source℠:
- ALZET® Osmotic Pumps Mechanism Video
- ALZET® Osmotic Pumps Surgical Implantation Techniques Video
- Lab Animals with ALZET® Osmotic Pumps Video
To learn more about ALZET® Osmotic Pumps, visit www.alzet.com.
ALZET® is a registered trademark of DURECT Corporation.