Neuroscience 2021

DATE

November 8-11, 2021

LOCATION

Virtual

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Accelerate your program with new tools and a collaborative, integrated approach that fuels the transition from in vitro biology right into the clinic. Our partnership provides the support you need to conquer the most challenging obstacles of your neuroscience drug discovery programs and accelerate your time to market.

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Virtual Panel Discussion: Human Translational Neuroscience

For the last 15 years, the World Health Organization (WHO) has pinpointed brain disorders as ‘one of the greatest threats to public health’ with one in four people affected by neurological or mental health conditions at some point in their lives. While there is currently a host of treatments for these disorders, there are no cures. Translational neuroscience aims to resolve this by transforming knowledge gained from basic science into interventions and applications for treating human disease. In the absence of a “perfect,” model, some approaches combine existing animal models and human induced pluripotent stem cell models to increase the translatability of results. To understand why past decades of research have failed to result in successful treatments, we must understand the impact of human translational neuroscience research.

Moderator

 

Headshot of Toni Ahtoniemi.

 

Toni Ahtoniemi, PhD

Associate Director, Client Services at Charles River

Read Toni’s bio and publications

 

 

Panelists

 

Headshot of Lowry Curley.

 

Lowry Curley

Chief Executive Officer at AxoSim Inc. 

 

 


Headshot of mark kotter.

 

Mark Kotter

Founder and CEO of Bit Bio

 

 


Headshot of Simon Authier.

 

Simon Authier

Senior Director of Scientific Operations and Veterinary Science

 

 

 

This year for the Society for Neuroscience (SfN) annual meeting, we decided to look to the future. We took as our basis a timeline created by SfN for their 50th anniversary, and invited experts in their fields to comment on the milestones projected on the timeline.

 

Check out our posters at this year's SfN annual meeting:

Cognition: Animal Models of Schizophrenia

Poster #4619: Roluperidone (MIN-101) Causes Brain Region-Specific Neurotransmitter Release, Increased Brain Activity and Functional Network Connectivity in the Rat Brain Related to Negative Symptoms in Schizophrenia
Takeda in Collaboration With Charles River

Drug Delivery and Formulation

ePoster Presentation Available

Poster #9258: Advances in Gene Therapy: Convection enhanced delivery for Parenchymal Brain Administration guided by real time MRI
Erik Larson, Charles River

Huntington's Disease: Models

Poster #5557: Evaluation of marmoset as possible non-human primate model for HTT splicing modulation studies
Charles River in Collaboration With CHDI
Maria Herva Moyano, Charles River

ePoster Presentation Available

Poster #3529: Next generation reprogramming of human iPSCs to generate disease-specific glutamatergic neurons carrying HTT gene for Huntington’s disease research and drug discovery
Mariangela Iovino, Charles River

Huntington's Disease: Preclinical Interventions

Poster #679: Evaluation of a small molecule splicing modulator in a humanized HTT intron 49 mouse
Charles River in Collaboration With CHDI
Dario Magnani, Charles River

Poster #692: Profiling of a novel orally active and brain penetrant splicing modulator small molecule demonstrates CNS and systemic mHTT lowering in BACHD mice
Charles River in Collaboration With CHDI
Maria Herva Moyano, Charles River

Motor Neuron Disease: Therapeutics

ePoster Presentation Available

Poster #3257: High-throughput screening (HTS) for identification of a tool compound targeting the interaction of SRSF1 with C9orf72 to prevent nuclear export in ALS and FTD
Rhea van de Bospoort, Charles River

Single-Cell Techniques II

Poster #3197: Huntington's disease (HD) human embryonic stem cells (hESCs) with mono-allelic HTT exon 12 genomic barcoding show applicable pharmacological responses, retain relevant neuronal differentiation capacity and demonstrate allele selectivity screening potential
Charles River in Collaboration With CHDI
Martin Brown, Charles River

Voltage-Gated Sodium Channels

ePoster Presentation Available

Poster #1031: Identifying Novel and Selective Sodium Channel Modulators from Theraphosidae Venoms
Charles River in Collaboration With Venomtech
Elaine Duncan, Charles River

Featured ePoster
Advances in Gene Therapy: Convection Enhanced Delivery for Parenchymal Brain Administration Guided by Real Time MRI
Presented by Erik Larson, Charles River

 

 

Download the PDF

 


Featured ePoster
High-throughput Screening (HTS) for Identification of a Tool Compound Targeting the Interaction of SRSF1 with C9orf72 to Prevent Nuclear Export in ALS and FTD

Presented by Rhea van de Bospoort, Charles River

 

 

Download the PDF


Featured ePoster
Identifying Novel and Selective Sodium Channel Modulators from Theraphosidae Venoms

Charles River in Collaboration With Venomtech
Elaine Duncan, Charles River

 

Download the PDF

 


Featured ePoster
Next Generation Reprogramming of Human iPSCs to Generate Disease-specific Glutamatergic Neurons Carrying HTT Gene for Huntington’s Disease Research and Drug Discovery

Mariangela Iovino, Charles River

 

Download the PDF

 

Empower your program with insights from our team – browse our collection of neuroscience resources.

 

Browse All Neuroscience Resources

 

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Viral Vector Resources

Learn more about our many neuroscience research tools, including viral vectors, biosensors, and Parkinson’s Disease tools.

Browse The Resources

 

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The Webinar Collection

Learn more about our neuroscience portfolio by watching our webinar series.

Browse the Webinars

 

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Neuroscience In Vitro Services: A Virtual Tour

Our collection of neuroscience-focused in vitro services are highlighted in this all-encompassing virtual tour of our facilities.

Watch the Video