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Collaborating with Regeneron
Germ-Free Mice: Models, Products, and Services
Germ-free mice are essential to microbiome research and the production of specific pathogen-free (SPF) rodent models. Research into the role of microbiota in health and disease has increased during the past decade due to the development of genetically engineered mutant animal models.
Research Mouse Models
High Quality Mouse Models for Biomedical Research
With more than 20 breeding facilities around the world, Charles River is the leading global supplier of standard mouse models for biomedical research.
Charles River stocks and strains are managed under the International Genetic Standardization (IGS) program, a unique program designed to manage the health and genetics of outbred and inbred strains on a global basis, ensuring that researchers worldwide have access to standardized models, regardless of the production location.
In Vivo Endocrine Disruptor Assays
Overview of In Vivo Endocrine Disruptor Assays
Amphibian Metamorphosis Assay (21d) (OECD 231)
The Amphibian Metamorphosis Assay (AMA) is a screening assay intended to empirically identify whether test item may interfere with the normal function of the hypothalamic-pituitary-thyroid (HPT) axis.
In Vitro Endocrine Disruptor Assays
Overview of In Vitro Endocrine Disruptor Assays
Estrogen receptor binding assay using rat uterus cytosol (OPPTS 890.1250)
The estrogen receptor binding assay measures the ability of a radiolabeled ligand ([3H]-17β-estradiol) to interact with the ER in the presence of increasing concentrations of a test item. Rat uterine cytosol is the source of ERα.
Discovery and Safety Assessment Approaches for Small Molecule and Biological Therapeutics
Strategies to Expedite Translation to the Clinic
Join us for a Charles River Presents one-day symposium at Skolkovo BioMed Park in Moscow, Russia
In Vivo Microdialysis - Tumor Microenvironment
Sampling the Tumor Microenvironment
Pharmacological effects and pharmacokinetics of test compounds can be determined in the tumor microenvironment with high sensitivity and temporal resolution by in vivo microdialysis.