Functional Ultrasound Imaging

Functional Ultrasound Imaging

Preclinical Imaging of the Brain

In the brain, functional ultrasound imaging measures transient changes in blood volume at better spatiotemporal resolution than any other functional brain imaging technique. The readout is based on the well-known doppler effect where waves are reflected from red blood cells moving through blood vessels. The signals are directly proportional to relative cerebral blood volume (rCBV).

Product End-of-Life Policies

Product End-of-Life Policies

End-of-Life Technology

Products reach the end of their product lifecycle for a several reasons, such as rapid advancements in technology and the constantly evolving standards of care and maintenance. We continually strive to incorporate these factors to better serve our customers and provide solutions that ultimately put patient safety first.
 

Study-Ready Humanized Mouse Model

Study-Ready Humanized Mouse Model

HuPBMC-NCG Mouse

In vivo models engrafted with human immune cells are critical for immuno-oncology, infectious disease, and graft rejection research. Peripheral blood mononuclear cells (PBMCs) are of particular interest when humanizing mice because of their ability to quickly engraft in immunodeficient mice. The majority of mature human immune cells, when using PBMCs, are of human T cell origin (CD4+ and CD8+) within a week to 10 days.

Humanized Mice

Humanized Mice

Humanized Mouse Models

The use of humanized mice as in vivo models has become commonplace in studies for immuno-oncology and infectious disease research. They have also improved the ability to predict human responses to new drugs being clinically developed.

Depending on research requirements, it is critical that researchers have the ability to obtain study-ready animals or maintain the option to humanize the mice in-house to meet their project timeline.

Extended One Generation Reproductive Toxicity Study (EOGRTS)

Extended One Generation Reproductive Toxicity Study (EOGRTS)

EOGRTS: Study design considerations

Prior to study initiation, it is useful to have some background data on reproductive endpoints such as spermatogenesis (testicular histopathology) for males and ovarian integrity (histopathology) for females. Data from repeat-dose studies or short-term endocrine disrupter screening assays can also be used to evaluate effects on male and female reproductive organs.

Addressing Data Integrity in the QC Lab

Artificial Intelligence for Drug Discovery

Artificial Intelligence for Drug Discovery

Using AI for Protein Protein Interactions

AI can be more cost effective and efficient than traditional screening approaches for the assessment of difficult, intractable and atypical targets such as protein protein interactions.  By partnering with Charles River, clients have access to Atomwise AtomNetTM, a patented platform for the prediction of physical interactions of molecules. AtomNet predicts the binding affinity of small molecules for drug discovery applications using AI.

Rare Disease In Vitro Assays

Rare Disease In Vitro Assays

High-Content Imaging in Disease-Relevant Cell Models

Phenotypic assays using disease-relevant cell models are an efficient approach to discover new disease drivers, perform high-throughput screens of compound or antibody libraries, understand mechanism of action, and identify clinically relevant biomarkers.

Finding the Right Alternative Model for Regulatory Testing

Finding the Right Alternative Model for Regulatory Testing

Charles River is delighted to host a full day seminar in 's-Hertogenbosch on the theme of Finding the Right Alternative Model for Regulatory Testing. Our faculty of expert speakers represent diverse research areas from academia, industry and our preclinical site in 's-Hertogenbosch. In addition to offering an engaging day of scientific discussion, the seminar is also intended to provide the opportunity for you to network with fellow members of the scientific community.

Stem Cells for Drug Discovery

Stem Cells for Drug Discovery

Generating iPS Cells for Drug Discovery

The discovery of reprogramming patient derived somatic cells into induced pluripotent stem cells (iPSC) has offered a promising alternative as they can be used to generate large numbers of cells and varied tissue types. Our extensive experience in stem cell culturing and differentiation delivers a comprehensive stem cell portfolio resulting in reproducible cell populations (striatal and cortical neurons) and robust assay quality for HTS and cell based assays.

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