We invite you to explore the following collection of materials that describe research conducted at our Charles River Massachusetts facility.
Scientific Resources from Charles River Massachusetts
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Meet the Team at Charles River Massachusetts
Dr. Robert (Bob) Dunn
Scientific Director of Toxicology
Why Choose Charles River Massachusetts?
SCIENCE: Extend your R&D team with a full complement of chemistry, pharmacology, toxicology, and lab science experts, study directors and support personnel dedicated to your project. Seasoned scientific advisors who’ve been on your side of the bench will help you see around the corners and overcome challenges for a smooth path to clinic.
Isotopic Labeling Services
Flexible Custom Synthesis for Stable Isotopic Labeling
Your toughest challenge is our favorite project. Whether you require an internal standard for quantitative analysis in a clinical study, need to determine metabolic routes and rates, or require an assay substrate molecule that releases a labelled product distinct from the endogenous product molecules present in a cell or tissue sample, we can create a flexible custom synthesis that meets your stable isotopic labeling needs.
Ludwig Maximilian University of Munich - Research Areas
University of Cambridge - Research Areas
Metabolite Synthesis Services
Custom Metabolite Synthesis for Metabolite Profiling
Ensure you’re meeting regulatory drug metabolite requirements for safety with Charles River’s custom metabolite synthesis services. In the United States, FDA guidelines recommend that all human disproportionate drug metabolites accounting for greater than 10% of total exposure are assessed in safety studies. Our metabolite profiling chemistry team’s custom services deliver data packages that:
Off-the-Shelf Genetically Engineered Mice
Off-the-Shelf Genetically Modified Mice
Genetically engineered animals are constructed to more precisely model human phenotypes and pathologies, giving researchers a better way to explore mechanisms and greater confidence in the translational potential of their findings.
Proteomics Services and Quantitative Proteomics
Discovery Proteomics Services
Proteomics is widely applicable in biomarker discovery, disease research, drug discovery, and development. Proteomics services and techniques can be applied to the analysis of a single protein or used for the large-scale analysis of a specific proteome including protein abundances, protein modifications, protein-protein interactions, and protein-compound interactions.