Nuclear Magnetic Resonance (NMR) Spectroscopy

Nuclear Magnetic Resonance (NMR) Spectroscopy

Quantification of Compounds with NMR Spectroscopy

NMR gives detailed information of a chemical, not only on the atomic composition of the molecule, but especially on the chemical structure of the molecule, revealing exactly where the specific atoms are placed in the molecule.

ToxTracker® Assay

ToxTracker® Assay

ToxTracker® Assay for Mechanistic Insight into Genotoxic Properties of Compounds

ToxTracker® can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens by revealing genotoxic modes of action and a number of non-genotoxic modes of action, including oxidative stress, protein misfolding, and general cellular stress – all of which have been associated with increased cancer risk.

product code test

product code test

Axcess® Classification Plans  
Axcess® basic plan
Axcess® premium plan
AXCB01
AXCP01
Axcess® Accessories
MBT Galaxy system
MBT Pilot system
AXC81655
AXC81880
Axcess® MALDI Biotyper-CM Reagents
Bacterial test standard (BTS)
Matrix HCCA

Novopack Rodent Packaging

Novopack Rodent Packaging

Filtered Crate for SPF Rodent Shipments from France

In order to provide a clear view of animals throughout the transportation process, three observation openings with a red plastic film have been specially designed and added to the top of the crate. A key benefit of the new Novopack is how the red film allows for ample observation during transport, while protecting animals from overexposure of light. Studies have shown that rodent retinas do not contain red cones, making mice and rats 12 times less sensitive to red light than humans.*

Charles River Prize

Charles River Prize

Charles River Prize in Laboratory Animal Science and Medicine

The Charles River Prize is awarded to a veterinarian in recognition of his/her outstanding contributions to laboratory animal science and medicine.


Background

Since 1978, Charles River has proudly sponsored the Charles River Prize in the United States. Beginning in 2013, we expanded the reach of the Charles River Prize to include our international colleagues through AALAS.

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Immunology

Immunology

The study of the different components of the immune system is critical for discovery and development of safe and effective therapeutics.

Providing Horseshoe Crabs a Jump Start on Life

Alternative Health Monitoring

Alternative Health Monitoring

Alternative Health Monitoring Programs

Animal research facilities are moving toward a sentinel-free system to help reduce the use of research animals and improve pathogen surveillance. Screening samples from the environment instead of the animal via more sensitive methods, such as Exhaust Air Dust (EAD®) or environmental PCR testing, allows you to reduce or eliminate the need for sentinel animals.

In Vitro MultiFlow® Assay

In Vitro MultiFlow® Assay

Overview

The MultiFlow® assay is a mode of action (MOA) assay in TK6 cells to evaluate potential genotoxic response to a test article or its metabolites. By assessing nuclear translocation and binding of p53, the assay discriminates genotoxicants from non-genotoxicants. Furthermore, double strand DNA breaks and mitotic checkpoint delays (G2/M block) results in persistent γH2AX foci and phosphorylation of H3, respectively (further discriminating clastogenicity from aneugenicity).

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