Gastric Cell Line: NCI-N87

• In Vivo Activity of ARRY-334543, a Potent, Small Molecule Inhibitor of EGFR/ErbB-2 in combination with trastuzumab or docetaxel
• XL888, a Novel, Synthetic, Orally Bioavailable Inhibitor of HSP90
• Ron in Breast Development and Cancer

NU/NU Nude Mouse

• γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin

CD-1 Nude Mouse

• Lapatinib, a Dual EGFR and HER2 Kinase Inhibitor, Selectively Inhibits HER2-Amplified Human Gastric Cancer Cells and is Synergistic with Trastuzumab In vitro and In vivo

Fox Chase SCID Mouse (C.B.17 SCID)

• Internal Xenograft Data