Ovarian Cell Line SK-OV-3

• Internal Xenograft Data
• RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

NU/NU Nude Mouse

• Decreased Src Tyrosine Kinase Activity Inhibits Malignant Human Ovarian Cancer Tumor Growth in a Nude Mouse Model
• Targeted Tumor Killing via an Intracellular Antibody against erbB-2
• Progesterone Receptor Membrane Component-1Regulates the Development and Cisplatin Sensitivity of Human Ovarian Tumors in Athymic Nude Mice

Fox Chase SCID Mouse (C.B.17 SCID)

• Enhanced Therapeutic Efficacy for Ovarian Cancer with a Serotype 3 Receptor-Targeted Oncolytic Adenovirus
• Potent Preclinical Impact of Metronomic Low-Dose Oral Topotecan Combined with the Antiangiogenic Drug Pazopanib for the Treatment of Ovarian Cancer
• Targeted Tumor Killing via an Intracellular Antibody against erbB-2

Fox Chase SCID Beige Mouse

• Spontaneous Malignant Transformation of Human Ovarian Surface Epithelial Cells in Vitro
• The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis

BALB/c Nude Mouse

• Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer