Charles River Partners with Pfizer

Charles River is a key provider of research models and services for Pfizer. Our goal is to provide the highest standards of service and quality in everything we do, so that the scientists at Pfizer can be empowered to focus on what matters most – furthering the understanding of biomedical science.

Do you have a question or want to brainstorm? Our Account Manager is available to support your research models and services needs.

Connect with Account Manager 

technician holding a mouse model

Charles River Offers Embryology Services & Contract Breeding
of Genetically Engineered Mice and Rats

isolator cages

Charles River provides a complete portfolio of embryology services including cryopreservation, rederivation, model creation and rapid colony expansion. 

Request Special Pricing
 

 

Model Evaluation Program

lab technician working with isolator cagesDo you wish to trial a model to test suitability before making a purchase? Explore our free animal model evaluation program.

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If you need a highly immunodeficient mouse model...

lab technician holding a white mouse

Our NCG mouse model is the most highly immunodeficient mouse and the model of choice for cancer xenograft modelling, stem cell biology, humanized mice, and infectious disease research.

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Explore the Tumor Microenvironment

tumor

Solve your challenges and maximize your assets by diving in to our TME explorer. Browse or search TME cell types to discover investigative approaches, relevant assays, and services designed to advance your research. Have a question? Our experts are ready to help.

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Our new quality of service (QOS) tool ensures you receive accurate estimates quickly. You can easily request a quote online for any of your genetically engineered models and service needs – whether it’s for model creation, cryopreservation, or breeding, among others.

Request a Quote


We've made it easier than ever to place a research animal model order. Your order will be immediately  sent to our customer service team for fulfillment. 

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Our Internet Colony Management (ICM™) system provides 24-hour access for researchers to manage their animal colonies and data. Review real-time data captured cageside and direct action within your colony.

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Discover scientific, technical, and medical research on ScienceDirect.

Explore ScienceDirect

Like you, we believe there is a cure. Illustrating our mission and services in context, our dedicated oncology page is designed to be your single source destination for the latest data, resources, and success stories in our field. We invite you to take a deep dive into your topics of interest by browsing our collection of articles, blog posts, webinars, and more. Meet our scientific team, discover what motivates them, and learn about their areas of focus. Get instant access to data tools that can accelerate your research, and sign up for the monthly Fast 5 industry news digest.


Explore Charles River Oncology

Humanized mouse models are beneficial tools for immuno-oncology and infectious disease research. They have improved the ability to predict human responses to new therapeutics in clinical development.

When your research requires humanized animal models, Charles River offers multiple options, both founded on the NCG triple-immunodeficient mouse.

•   CD34+ Humanized Mouse Model
•   PBMC Humanized Mouse Model
•   NCG/PBMC Select Humanization Kit


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Research Models and Services


Genetically Engineered Models and Services (GEMS) 
Our GEMS division offers a wide variety of services from breeding to model creation. Our decades of experience and vast network of vivariums around the world gives us the opportunity to offer an unparalleled selection of custom models and services to meet your unique needs. Researchers at Columbia receive many discounts off services provided by GEMS. Use our quoting tool to view the best price for your study.
 

Model Creation Services
Our experts can guide you through the model creation process.

Embryology Services
Our embryology services will help you protect your lines and generate new ones. 
•   Our cryopreservation services can protect your lines from genetic drift, natural disasters, and catastrophic events.
•   Rederivation can help you obtain animals that are free of infectious agents.   
•   Rapid colony development uses sophisticated IVF technology to generate animal colonies quickly.

Animal Model Evaluation
Select the right animal model for your study by trialing our free model evaluation program. Reduce risk by assessing the quality of our models on your own terms and at no cost. 

Try Out a Model


Humanized Mice
Humanized mouse models are beneficial tools for immuno-oncology and infectious disease research. They have improved the ability to predict human responses to new therapeutics in clinical development. It is critical that researchers have the ability to obtain study-ready animals project timelines and study requirements.

Trial Our HuCD34 Model

Oncology Services

•   Chemistry services
By working with our chemists right from the beginning, you can optimize the best version of your compound.

•   In vitro cell biology assays
2D and 3D cell assays using patient-derived materials and the cells of the tumor microenvironment allow us to accurately model human cancers.

•   Predictive immunotoxicology
Assays and models to mitigate risk of progressing your drug.

•   In vivo pharmacodynamic screening model
To allow the function of a therapeutic to be examined before entering a disease-specific model.

•   In vivo oncology efficacy models
You can test your drug in fully characterized patient-derived xenografts in our custom humanized models, with the option to implant as orthoptopic models for greater disease relevance, to truly represent the human disease state.

•   Oncology analysis
Ex vivo services, such as tumor microdialysis, sample the tumor microenvironment to further aid in your decision making.

•   Safety assessment and toxicology
Our extensive regulatory knowledge aids translation to the clinic, which is especially important for cell and gene therapies where discovery and safety studies will be closely linked.

Guidebooks
Check out our free, digital laboratory animal guidebooks on infection surveillance of rodents and colony management for mice and rats.
•   Modern Strategies for Infection Surveillance
•   Mouse and Rat Colony Management 
Publications
•   Targeting the Human MUC1-C Oncoprotein with an Antibody-Drug Conjugate
JCI Insight, 2018)

•   Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice
Molecular Therapy – Methods & Clinical Development, 2017)

•  Accumulation of Cytoplasmic CDC25A in Cutaneous Squamous Cell Carcinoma Leads to a Dependency on CDC25A for Cancer Cell Survival and Tumor Growth
(Cancer Letters, 2017)

Webinars
•   Upcoming
•   On demand
•   GEMS webinars, covering cryopreservation to CRISPR/Cas9 model creation
•   Germ-Free Colony Management
•   Maintaining a Static Microbiome Across Research Projects: Can It Be Done?
•   Immuno-oncology/oncology
•   Continuous Improvements in Humanized Mouse Models
•   Finding the Right Humanized Model for Your Research
•  The Value of Bioinformatics to Assess Novel Immuno-Oncology Therapies
•  The Right Tools to Optimize Cell Therapies for Oncology 
•  Oncologists: What Antibodies Can Do for You
•  When Immune Cells Invade a Tumor: Using the TME to Drive Your Oncology Research 

Additional Areas of Interest
Our team of Research Model Specialists offer free educational seminars on a variety of topics, including: 
•   Rare Disease
•   Immunology
•   Vaccine Development
•   Anti-Infective Studies
Posters
•   Common Rodent Health Conditions
•   Metabolic Diseases
•   Immunodeficient Mice
Regulatory Training and Continuing Professional Development
Charles River Insourcing Solutions℠ provides high-quality training and continuing professional development for veterinarians, scientists, lab technicians, and anyone else working in the field of animal research. Courses for rodents, zebrafish, and other CPD courses include NACWO, NTCO, a law refresher course, and more. 

In person and eLearning options are both available. See our upcoming courses at a location near you, or contact [email protected] about delivering a course at your facility.
 
ARRIVE Guidelines
Read more on ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments), which include clear guidance on research model nomenclature guidelines and other reporting criteria. 

 

 

How can I get information about special offers on research model and services?
Please contact [email protected] or call/text 000-000-0000.
What is your evaluation program?
Our evaluation program offers free research models to clients that have not used a strain to evaluate the quality and compatibility of our animal models with their research before making a commitment. Whether you have a new research protocol, are conducting or fine-tuning a pilot study, or simply exploring the opportunity to switch to a new animal model, this program can help you make the right choice.
Do you have any COVID-19 related resources? 
Yes. Take a look at our COVID-19 resources. A popular model for work on SARS-CoV-2 is Syrian Hamsters.
Do you have aged C57BL/6 mice?
Yes. We have an aged C57BL/6 colony. 
Are health reports available?
Yes. Health reports are available for research animal models bred by Charles River in North America.
Where can I find additional educational resources? 
See our expanded digital resources.
Do you provide information on infectious agents? 
Yes. Understanding infectious agents that can contaminate your research animal facility allows you to develop a plan to manage or prevent an outbreak. Our technical sheets contain information on viruses, bacteria/fungi, and parasites prevalent in laboratory animals.
When can I expect delivery? 
Delivery days for Pfizer are Tuesdays and Thursdays. 
How do I contact Charles River? 
Please contact our US client services team directly:
•   Email: [email protected]
•   Phone: 1-800-522-7287