Charles River Offers Embryology Services & Contract Breeding
of Genetically Engineered Mice and Rats
Model Evaluation Program
Do you wish to trial a model to test suitability before making a purchase? Explore our free animal model evaluation program.
Trial a Model
If you need a highly immunodeficient mouse model...
Our NCG mouse model is the most highly immunodeficient mouse and the model of choice for cancer xenograft modelling, stem cell biology, humanized mice, and infectious disease research.
Explore the Tumor Microenvironment
Solve your challenges and maximize your assets by diving in to our TME explorer. Browse or search TME cell types to discover investigative approaches, relevant assays, and services designed to advance your research. Have a question? Our experts are ready to help.
Our new quality of service (QOS) tool ensures you receive accurate estimates quickly. You can easily request a quote online for any of your genetically engineered models and service needs – whether it’s for model creation, cryopreservation, or breeding, among others.
We've made it easier than ever to place a research animal model order. Your order will be immediately sent to our customer service team for fulfillment.
Our Internet Colony Management (ICM™) system provides 24-hour access for researchers to manage their animal colonies and data. Review real-time data captured cageside and direct action within your colony.
Discover scientific, technical, and medical research on ScienceDirect.
Like you, we believe there is a cure. Illustrating our mission and services in context, our dedicated oncology page is designed to be your single source destination for the latest data, resources, and success stories in our field. We invite you to take a deep dive into your topics of interest by browsing our collection of articles, blog posts, webinars, and more. Meet our scientific team, discover what motivates them, and learn about their areas of focus. Get instant access to data tools that can accelerate your research, and sign up for the monthly Fast 5 industry news digest.
Humanized mouse models are beneficial tools for immuno-oncology and infectious disease research. They have improved the ability to predict human responses to new therapeutics in clinical development.
When your research requires humanized animal models, Charles River offers multiple options, both founded on the NCG triple-immunodeficient mouse.
Research Models and Services
Genetically Engineered Models and Services (GEMS)
Our GEMS division offers a wide variety of services from breeding to model creation. Our decades of experience and vast network of vivariums around the world gives us the opportunity to offer an unparalleled selection of custom models and services to meet your unique needs. Researchers at Columbia receive many discounts off services provided by GEMS. Use our quoting tool to view the best price for your study.
Model Creation Services
Our experts can guide you through the model creation process.
Our embryology services will help you protect your lines and generate new ones.
• Our cryopreservation services can protect your lines from genetic drift, natural disasters, and catastrophic events.
• Rederivation can help you obtain animals that are free of infectious agents.
• Rapid colony development uses sophisticated IVF technology to generate animal colonies quickly.
Animal Model Evaluation
Humanized mouse models are beneficial tools for immuno-oncology and infectious disease research. They have improved the ability to predict human responses to new therapeutics in clinical development. It is critical that researchers have the ability to obtain study-ready animals project timelines and study requirements.
Trial Our HuCD34 Model
• Chemistry services
Check out our free, digital laboratory animal guidebooks on infection surveillance of rodents and colony management for mice and rats.
• Modern Strategies for Infection Surveillance
• Mouse and Rat Colony Management
• Targeting the Human MUC1-C Oncoprotein with an Antibody-Drug Conjugate
JCI Insight, 2018)
• Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice
Molecular Therapy – Methods & Clinical Development, 2017)
• Accumulation of Cytoplasmic CDC25A in Cutaneous Squamous Cell Carcinoma Leads to a Dependency on CDC25A for Cancer Cell Survival and Tumor Growth
(Cancer Letters, 2017)
|Additional Areas of Interest
Our team of Research Model Specialists offer free educational seminars on a variety of topics, including:
• Rare Disease
• Vaccine Development
• Anti-Infective Studies
• Common Rodent Health Conditions
• Metabolic Diseases
• Immunodeficient Mice
|Regulatory Training and Continuing Professional Development
Charles River Insourcing Solutions℠ provides high-quality training and continuing professional development for veterinarians, scientists, lab technicians, and anyone else working in the field of animal research. Courses for rodents, zebrafish, and other CPD courses include NACWO, NTCO, a law refresher course, and more.
In person and eLearning options are both available. See our upcoming courses at a location near you, or contact [email protected] about delivering a course at your facility.
Read more on ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments), which include clear guidance on research model nomenclature guidelines and other reporting criteria.
|How can I get information about special offers on research model and services?
Please contact [email protected] or call/text 000-000-0000.
|What is your evaluation program?
Our evaluation program offers free research models to clients that have not used a strain to evaluate the quality and compatibility of our animal models with their research before making a commitment. Whether you have a new research protocol, are conducting or fine-tuning a pilot study, or simply exploring the opportunity to switch to a new animal model, this program can help you make the right choice.
|Do you have any COVID-19 related resources?
Yes. Take a look at our COVID-19 resources. A popular model for work on SARS-CoV-2 is Syrian Hamsters.
|Do you have aged C57BL/6 mice?
Yes. We have an aged C57BL/6 colony.
|Are health reports available?
Yes. Health reports are available for research animal models bred by Charles River in North America.
|Where can I find additional educational resources?
See our expanded digital resources.
|Do you provide information on infectious agents?
Yes. Understanding infectious agents that can contaminate your research animal facility allows you to develop a plan to manage or prevent an outbreak. Our technical sheets contain information on viruses, bacteria/fungi, and parasites prevalent in laboratory animals.
|When can I expect delivery?
Delivery days for Pfizer are Tuesdays and Thursdays.
|How do I contact Charles River?
Please contact our US client services team directly:
• Email: [email protected]
• Phone: 1-800-522-7287