3D Tumor Models
In conjunction with our drug sensitivity and molecular characterization data, our 3D tumor models allow you to evaluate the potency of your compound compared to standard-of-care drugs.
Oncology CAR-T and Cell Therapy Testing Solutions
Our team of scientific and regulatory advisors can advise how to collect the data you need to progress your therapy to the clinic, so you can get your CAR-T therapies to cancer patients faster.
Tumor-infiltrating lymphocyte (TIL) or tumor gene expression analysis
Our gene expression technology may be used to screen a wide range of cellular, biologic, or small molecule therapeutics targeting anti-tumor immunity in rodent models.
Bioinformatics: Mining Big Data to Discover Precision Oncology Therapies
Mining big data can help accurately stratify patients who will respond to your therapy, driving decisions and allowing you to bring your best anti-cancer therapies further into development.
View and download posters from the Society for Immunotherapy of Cancer's 35th Anniversary Annual Meeting & Pre-Conference Programs.
View and download posters from the 2020 meeting of the American Association for Cancer Research.
Our new quality of service (QOS) tool ensures you receive accurate estimates quickly. You can easily request a quote online for any of your genetically engineered models and service needs – whether it’s for model creation, cryopreservation, or breeding, among others.
Place an Animal Order
We've made it easier than ever to place a research animal model order. Your order will be immediately sent to our customer service team for fulfillment.
Internet Colony Management (ICM)
Our Internet Colony Management (ICM™) system provides 24-hour access for researchers to manage their animal colonies and data. Review real-time data captured cageside and direct action within your colony.
Laboratory Testing Management
LTM™ has been designed to be an easy-to-use system that help you to streamline your sample submission, result reporting and tracking processes for your animal diagnostic needs.
The right partner can help you win the race to reach patients first. From basic research to IND and every stage in between, we’re dedicated to helping you reach your goals. Our proven track record speaks for itself.
By working with our chemists right from the beginning, you can optimize the best version of your compound.
|In Vitro Cell Biology Assays
2D and 3D cell assays using patient-derived materials and the cells of the tumor microenvironment allow us to accurately model human cancers.
Assays and models to mitigate risk of progressing your drug.
|In Vivo Pharmacodynamic Screening Model
To allow the function of a therapeutic to be examined before entering a disease-specific model.
In Vivo Oncology Efficacy Models You can test your drug in fully characterized patient-derived xenografts in our custom humanized models, with the option to implant as orthoptopic models for greater disease relevance, to truly represent the human disease state.
Ex vivo services, such as tumor microdialysis, sample the tumor microenvironment to further aid in your decision making.
|Safety Assessment and Toxicology
Our extensive regulatory knowledge aids translation to the clinic, which is especially important for cell and gene therapies where discovery and safety studies will be closely linked.
Research Models & Services
|Genetically Engineered Models and Services (GEMS)
Our GEMS division offers a wide variety of services from breeding to model creation. Our decades of experience and vast network of vivariums around the world gives us the opportunity to offer an unparalleled selection of custom models and services to meet your unique needs. Researchers at Columbia receive many discounts off services provided by GEMS. Use our quoting tool to view the best price for your study.
|Model Creation Services
Our experts can guide you through the model creation process.
Our embryology services will help you protect your lines and generate new ones.
• Our cryopreservation services can protect your lines from genetic drift, natural disasters, and catastrophic events.
• Rederivation can help you obtain animals that are free of infectious agents.
• Rapid colony development uses sophisticated IVF technology to generate animal colonies quickly.
Animal Model Evaluation
Humanized mouse models are beneficial tools for immuno-oncology and infectious disease research. They have improved the ability to predict human responses to new therapeutics in clinical development.
When your research requires humanized animal models, Charles River offers multiple options, both founded on the NCG triple-immunodeficient mouse.
Check out our free, digital laboratory animal guidebooks on infection surveillance of rodents and colony management for mice and rats.
• Modern Strategies for Infection Surveillance
• Mouse and Rat Colony Management
• Targeting the Human MUC1-C Oncoprotein with an Antibody-Drug Conjugate
JCI Insight, 2018)
• Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice
Molecular Therapy – Methods & Clinical Development, 2017)
• Accumulation of Cytoplasmic CDC25A in Cutaneous Squamous Cell Carcinoma Leads to a Dependency on CDC25A for Cancer Cell Survival and Tumor Growth
(Cancer Letters, 2017)
|Additional Areas of Interest
Our team of Research Model Specialists offer free educational seminars on a variety of topics, including:
• Rare Disease
• Vaccine Development
• Anti-Infective Studies
• Common Rodent Health Conditions
• Metabolic Diseases
• Immunodeficient Mice
|Regulatory Training and Continuing Professional Development
Charles River Insourcing Solutions℠ provides high-quality training and continuing professional development for veterinarians, scientists, lab technicians, and anyone else working in the field of animal research. Courses for rodents, zebrafish, and other CPD courses include NACWO, NTCO, a law refresher course, and more.
In person and eLearning options are both available. See our upcoming courses at a location near you, or contact [email protected] about delivering a course at your facility.
Read more on ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments), which include clear guidance on research model nomenclature guidelines and other reporting criteria.
|How can I get information about oncology services?
|How can I get information about special offers on research model and services?
Please contact [email protected] or call/text 000-000-0000.
|What is your evaluation program?
Our evaluation program offers free research models to clients that have not used a strain to evaluate the quality and compatibility of our animal models with their research before making a commitment. Whether you have a new research protocol, are conducting or fine-tuning a pilot study, or simply exploring the opportunity to switch to a new animal model, this program can help you make the right choice.
|Do you have any COVID-19 related resources?
Yes. Take a look at our COVID-19 resources. A popular model for work on SARS-CoV-2 is Syrian Hamsters.
|Do you have aged C57BL/6 mice?
Yes. We have an aged C57BL/6 colony.
|Are health reports available?
Yes. Health reports are available for research animal models bred by Charles River in North America.
|Where can I find additional educational resources?
See our expanded digital resources.
|Do you provide information on infectious agents?
Yes. Understanding infectious agents that can contaminate your research animal facility allows you to develop a plan to manage or prevent an outbreak. Our technical sheets contain information on viruses, bacteria/fungi, and parasites prevalent in laboratory animals.
|When can I expect delivery?
Delivery days for Pfizer are Tuesdays and Thursdays.
|How do I contact Charles River?
Please contact our US client services team directly:
• Email: [email protected]
• Phone: 1-800-522-7287