Overview

Charles River offers a portfolio of in vivo, in vitro and biochemical viral safety assays. Assays can be chosen and customized to address your specific concerns and needs, ensuring that an appropriate testing plan is designed for your product. Fast Track Testing is also available for quick delivery of urgently needed results.

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In Vivo Assays

  • Mouse, hamster and rat antibody production (MAP, HAP, RAP) test
  • Adventitious virus assays, including specific assays for the testing of vaccines

Cell-Based In Vitro Assays

  • 14- and 28-day adventitious agent assays
  • Porcine and bovine adventitious agent assays
  • Customized assays addressing specific contamination risks
  • Retrovirus detection assays
  • XC plaque assay
  • S+L- focus assay
  • Transmission electron microscopy (TEM)
  • Co-cultivation assays (murine, ecotropic, amphotropic and rodent)
  • PCR-based reverse transcriptase (PBRT) assay

Species-Specific Viral PCR Assays

  • Standard and qPCR techniques available for RNA and DNA viruses
  • Method development available for customized assays
  • Rapid, sensitive and specific broad-range PCR assays for adenoviruses, herpesviruses, papillomaviruses and polyomaviruses
  • Retroviral enzyme activity (reverse transcriptase)