Many of our biophysical characterization methodologies examine a biologic’s higher-order structure, which may include secondary and tertiary structure, aggregation, and oligomerization. Calorimetric assays are used in stability assessment and formulation development, and surface plasmon resonance (SPR) is a functional assay for binding affinity against a target compound or against effector functionality as in Fc receptor binding. The assays below form a core capability within the Biophysics Group at Charles River.

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Secondary and Higher-Order Structural Characterization Methods