Overview

With extensive experience managing complex mass spectrometry projects, our state-of-the-art facility consistently delivers excellent structural characterization and proteomic analytical services. Offerings provided to our clients’ include:

  • Host Cell Protein (HCP) analysis
  • Quantitative proteomics using Tandem Mass Tags (TMT), absolute quantification (AQUA), and label-free quantitation 
  • Cellular/tissue proteomic PTM identification and quantification including, phosphorylation pathway mapping/profiling, acetylation, methylation, and ubiquitination
  • Glycosylation site mapping and site occupancy determination
  • Peptide mapping of antibodies and complex glycoproteins
  • Disulfide bond mapping and isoform characterization 
  • PEGylation site mapping
  • Antibody drug conjugate (ADC) stoichiometry and conjugation-site characterization
  • Intact and subunit molecular weight determination
  • Glycan structural characterization, including de novo analysis
  • MALDI-TOF-MS for complex glycoproteins 
  • GAGS, heparin, and heparan sulfate 
  • De novo amino acid sequencing, including Ile/Leu determinations
  • Peptide mapping method development for ICH validation and GMP lot release
  • Biosimilars comparability and characterization programs
  • Degradation, forced degradation, and stability studies 
  • Reference standard characterization

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