Due to the complexity of rAAV therapies, Charles River has developed specialized testing packages for the characterization and quality control testing of AAV particles and constituent capsid protein assemblies. The packages include:

  • Mass Spectrometry
    • Peptide mapping
    • Intact molecular weight
    • Glycan profiling of viral envelope proteins
  • Biophysical Characterization (Higher Order Structure Analysis)
    • Analytical ultracentrifugation for determine of empty vs. full capsid ratios
    • Stability indicating methods such as DSC and DLS
  • Analytical Testing
    • RP-HPLC
    • Anion exchange HPLC
    • ELISA methods
    • Amino acid analysis
    • N-terminal sequencing

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