Discovery Services

In this unprecedented climate of change and uncertainty, we in the research community are faced with all new challenges. Now more than ever, we know your work must continue for the patients who are waiting for new therapies. Our Discovery team is prepared and equipped to support you through these times and keep your research moving forward.


View All Discovery Services and Facilities

Image of women preparing microtiter plates for High-Throughput Screening. These plates contain cell-based assays for that will provide data to identify targets or leads and optimize compounds for use in drug discovery and development.

Discovering and characterizing novel drug candidates for preclinical development depends on innovative and reliable science. Our unique combination of integrated, multidisciplinary drug discovery expertise and unparalleled scope of capabilities in targets, platforms, and therapeutic areas allow us to deliver depth and breadth in science with data and insight you can trust to progress your drug discovery programs.

Integrated Drug Discovery

Time to clinic can be reduced by one year with an integrated drug discovery approach, whereby target discovery, hit id, hit-to-lead, lead optimization, safety, and toxicology is managed by the same project team.

Pharmacology Studies

In vitro to in vivo translation is difficult, costly, and often fails. Advance your discovery research with our translationally focused approach across a range of therapeutic areas including Oncology, Neuroscience, and Immunology.

Screening and Profiling Assays

From target validation to lead identification and optimization, the right combination of biochemical and cell-based assays progresses translational success.

Chemistry

Discovery chemists guide key decisions by considering factors such as client intellectual property (IP) generation, compound stability for in vivo studies, solubility and other poor property issues, weak exposure in an animal, and off-target selectivity.

Pharmaceutical Sciences and Formulation

Generating a thorough pharmaceutical sciences data package provides crucial information to guide the selection of more robust candidates and to inform an efficient formulation strategy for preclinical studies.

DMPK/ADME

Leverage our comprehensive laboratory services such as DMPK/ADME, bioanalytical services, biomarker testing, immunology testing, formulation development, and clinical laboratory support.

Biologics Discovery and Protein Engineering

We can support your biologics project from lead identification to clinical candidate selection through the breadth of our state-of-the-art platforms and seasoned scientists.
The vital science logo. Image links to season 2, episode 9: Can a Repurposed Drug Be the Answer?

Vital Science Podcast: S2, E09: Can a Repurposed Drug Be the Answer?

What if the cure for your untreatable disease was just waiting on the shelf at your neighborhood pharmacy? Join physician, patient, and researcher Dr. David Fajgenbaum as he shares how his unexpected battle with Castleman disease set him on a journey to find his cure and develop new ways of using existing drugs.

Listen To the Podcast

graphic image of tumor for AACR 2021 signifying the oncology research done for AACR 2021 at Charles River

AACR 2021 Poster Resources

Whether you watch the videos or download them on-demand, you won’t want to miss the content of our scientific poster presentations that were presented at AACR 2021.

browse The Posters

graphic image of DNA to represent our bioinformatic services and data analysis

Bioinformatics Services

Bioinformatics goes hand-in-hand with the complex data derived from today’s next generation sequencing technologies. Get the sophisticated bioinformatics services you need to drive discovery and maximize your ROI when you partner with Charles River.

Learn More About Analyzing Complex Data