Discovery Services

In this unprecedented climate of change and uncertainty, we in the research community are faced with all new challenges. Now more than ever, we know your work must continue for the patients who are waiting for new therapies. Our Discovery team is prepared and equipped to support you through these times and keep your research moving forward.


View All Discovery Services and Facilities

Image of women preparing microtiter plates for High-Throughput Screening. These plates contain cell-based assays for that will provide data to identify targets or leads and optimize compounds for use in drug discovery and development.

Discovering and characterizing novel drug candidates for preclinical development depends on innovative and reliable science. Our unique combination of integrated, multidisciplinary drug discovery expertise and unparalleled scope of capabilities in targets, platforms, and therapeutic areas allow us to deliver depth and breadth in science with data and insight you can trust to progress your drug discovery programs.

Integrated Drug Discovery

Time to clinic can be reduced by one year with an integrated drug discovery approach, whereby target discovery, hit id, hit-to-lead, lead optimization, safety, and toxicology is managed by the same project team.

Pharmacology Studies

In vitro to in vivo translation is difficult, costly, and often fails. Advance your discovery research with our translationally focused approach across a range of therapeutic areas including Oncology, Neuroscience, and Immunology.

Screening and Profiling Assays

From target validation to lead identification and optimization, the right combination of biochemical and cell-based assays progresses translational success.

Chemistry

Discovery chemists guide key decisions by considering factors such as client intellectual property (IP) generation, compound stability for in vivo studies, solubility and other poor property issues, weak exposure in an animal, and off-target selectivity.

Pharmaceutical Sciences and Formulation

Generating a thorough pharmaceutical sciences data package provides crucial information to guide the selection of more robust candidates and to inform an efficient formulation strategy for preclinical studies.

DMPK/ADME

Leverage our comprehensive laboratory services such as DMPK/ADME, bioanalytical services, biomarker testing, immunology testing, formulation development, and clinical laboratory support.

Biologics Discovery and Protein Engineering

We can support your biologics project from lead identification to clinical candidate selection through the breadth of our state-of-the-art platforms and seasoned scientists.
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Innovation in Drug Discovery

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science, and our strong sense of purpose guide us in all that we do. Listen as we pause to celebrate the work of our partners and engage in meaningful conversation about the current state and future of scientific innovation and its impact on human health.

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Avoiding Off-Target Liabilities Using IHC and Cell Microarray Assays

What if you could get more data from your off-target screening, not only WHERE your off-target occurred, but also WHAT protein caused it? Watch this webinar as we present case studies that utilized technology trailblazers, IHC and Retrogenix Cell Microarray to achieve this distinction.

Watch The Webinar

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Neuroscience 2021

Join us as we celebrate five decades of neuroscience progression and introduce the newest innovations in the field. View our posters and initiate a conversation with our experts at our virtual, exhibit space. We look forward to applying our neuroscience mastery to your program and expediting your time to market.

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