Discovery Services

In this unprecedented climate of change and uncertainty, we in the research community are faced with all new challenges. Now more than ever, we know your work must continue for the patients who are waiting for new therapies. Our Discovery team is prepared and equipped to support you through these times and keep your research moving forward.
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Image of women preparing microtiter plates for High-Throughput Screening. These plates contain cell-based assays for that will provide data to identify targets or leads and optimize compounds for use in drug discovery and development.

Discovering and characterizing novel drug candidates for preclinical development depends on innovative and reliable science. Our unique combination of integrated, multidisciplinary drug discovery expertise and unparalleled scope of capabilities in targets, platforms, and therapeutic areas allow us to deliver depth and breadth in science with data and insight you can trust to progress your drug discovery programs.

Integrated Drug Discovery

Time to clinic can be reduced by one year with an integrated drug discovery approach, whereby target discovery, hit id, hit-to-lead, lead optimization, safety, and toxicology is managed by the same project team.

Chemistry

Discovery chemists guide key decisions by considering factors such as client intellectual property (IP) generation, compound stability for in vivo studies, solubility and other poor property issues, weak exposure in an animal, and off-target selectivity.

Screening & Profiling Assays

From target validation to lead identification and optimization, the right combination of biochemical and cell-based assays progresses translational success.

DMPK/ADME

Leverage our comprehensive laboratory services such as DMPK/ADME, bioanalytical services, biomarker testing, immunology testing, formulation development, and clinical laboratory support.

Pharmacology Studies

In vitro to in vivo translation is difficult, costly, and often fails. Advance your discovery research with our translationally focused approach across a range of therapeutic areas including Oncology, Neuroscience & Immunology.

Discovery Facilities

Explore the expansive global network that allows us to support your translational research from early discovery through preclinical studies. 
ONO-8590580, a GABAA α5-selective NAM that improves hippocampal memory

A New Development in Cognitive Disorder Treatments

GABAA α5 NAMs may offer therapeutic potential for the treatment of disorders such as Alzheimer’s disease, and recent discovery studies support this potential.

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Targeting Autoreactive B Cells

Targeting Autoreactive B Cells

Build a better targeted B cell therapy for autoimmune and inflammatory conditions like lupus and MS with assays that evaluate B cell function on distinct pathways.

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