With decades of experience running in vitro ADME assays and analyzing the data, we can offer those same in vitro assays and bioanalyses more efficiently to generate ADME data earlier in the drug discovery process. This high-speed process optimization and reproducibility can generate quality ADME data for every compound in your chemical library.
To help streamline the early drug-discovery process, we have successfully validated and deployed automation and IT infrastructure to enable rapid delivery of in vitro ADME results. The workflow enables up to 500 compounds per week to support primary assays:
- Microsomal stability
- Permeabililty (Caco-2 and MDCK-MDR1)
- Protein binding
- RBC partitioning (Blood/Plasma ratio)
High-Speed Data Acquisition
Figure 1: 160 permeability samples analyzed in 30 minutes
Below are manual vs. HT LC-MS/MS and automated liquid handling workflows using new chemical entities (NCEs) and marketed compounds.