Overview

Understanding the pharmacokinetics (PK) of a test article is an essential component of drug discovery and development programs. At Charles River, we are able to support rapid bioavailability screening during drug candidate design and selection as well as define the PK profile of compounds in the development phase.

Rapid PK Screening Overview

The iterative nature of in vivo PK screening requires rapid cycle times with changing priorities. We have built a team of experienced scientists with facilities and processes designed specifically to meet these challenging requirements. When combined with our discovery bioanalysis, Charles River provides you with standard PK parameters for non-compartmental analysis within five days of dosing.

From standard screening to more complex studies, our team of experienced study directors can also assist in designing the best strategy and protocols customized to suit any drug discovery program. Rapid study initiations facilitated by our maintenance supply of rodents and colonies of non-rodent species along with standardized protocols and fully integrated LC-MS/MS bioanalysis of PK samples, including small volume samples, result in better data faster.