Expert study designs, in vitro ADME assays and data interpretation from the in vitro ADME services group at Charles River allow you to characterize your drug candidate's ADME properties and its potential for drug interactions. We have focused on building efficient systems and procedures to meet the needs and timelines of clients working in the drug discovery and development environment. Many of our in vitro assays have multiple formats available to suit the different stages of the drug discovery and development pipeline, allowing us to offer a flexible approach to our ADME services. We offer a range of study design levels (SDLs) in our in vitro assay services. Each of our in vitro assays can be offered as an early screening (single time point or concentration) or a more definitive (IC50 or T1/2) study to estimate PK/ADME characteristics.


While Charles River has standard procedures for each of these assays listed below, our team of experienced study directors can also assist in designing the best strategy and protocols customized to suit any drug discovery need.