Overview

Capture compound mass spectrometry (CCMS) is based on:

  • Trifunctional molecules – Capture Compounds®
  • Chemistry knowhow for tailored design
  • Proprietary work flow
  • No solid matrix, in solution application
  • Specificity controls
  • Covalent crosslinking for high sensitivity

CCMS delivers a ranked short list of specific protein interactors for any small molecule. Watch the video to learn more.

 

Benefits & Applications

  • COMPOUND PROFILING

    CCMS-mediated target ID provides:

    • Identified targets for phenotypic compound-finding campaigns
    • ID of binding site and mode of interaction
    • Targets in any cellular compartment (e.g., GPCRs, ion channels, cytoplasmic signaling proteins and enzymes, nuclear proteins)
    • Proteins of low abundance
    • Deconvolution of targets for mechanism of action, adverse events, or toxicities in any tissue or species
    • Novel mechanistic targets for compound re-positioning

    Capture Compound Mass Spectrometry diagram

  • CHEMISTRY DECISION MAKING

    CCMS profiling enables:

    • Prediction of human toxicity liability
    • Guidance of lead optimization and regulatory programmes to help you choose the best development candidate
    • Replacement of assay development and screening
    • Avoidance of unexpected events in later development
    • Data-driven decision-making for crucial milestones
  • MANAGING RISK

    CCMS risk-prediction offers to collaborators:

    • Information-based decision making
    • Cross species comparisons
    • Tissue comparisons
    • Toxicity predictions
    • Compound-specific biomarkers
    • Personalized therapeutics
    • Better candidate selection
    • Development path design
  • SUPPORTING PROJECTS ACROSS DISCOVERY & DEVELOPMENT

    CCMS profiling can deliver:

    • Target deconvolution and identification from phenotypic screens
    • Drug discovery support
    • Biomarkers for personalization and product rescue
    • Product positioning
    • Compound re-purposing
    • Life cycle management support