Overview

SoftFocus® compound libraries have delivered outstanding success to partners that have screened them, as evidenced by numerous patents and published papers, and have led to several clinical candidates.

Screening small, focused libraries of novel compounds designed to address your biological target can:

  • provide valuable SAR and higher hit rates compared to diverse screening
  • give an improved chance of securing intellectual property (IP)
  • provide quality starting points for emerging or complex targets, if designed to contain the necessary features and shape
  • demonstrate utility in phenotypic screens

Our SoftFocus® libraries can be accessed through a shared exclusivity model, whereby access to each library is restricted to a maximum of 15 partners. Contact us for details on what libraries are currently available.

ASK US ABOUT OUR LIBRARIES

Current design targets
Epigenetic Libraries:
 
  • histone methyltransferase (HMT)
  • histone lysine demethylases (KDM)
  • bromodomains
Protein-Protein Interactions (PPI) Libraries:
 
  • secondary structure mimetics
  • ‘hot-spot’ targets
  • macrocyclic libraries
Kinase Libraries:
  • hinge binding
  • ‘DFG-out’
  • invariant lysine binding
GPCR Libraries:
  • Family A (including chemokine and lipid receptors)
  • Family C, such as mGluR
Ion Channel Libraries:
  • voltage-gated libraries (VGIC)
  • ligand-gated (LGIC)
  • transient receptor potential channels (TRP channels)