Overview

Charles River has experience with many targets of pharmaceutical interest covering a range of gene families, including kinases (Ser/Thr and Tyr), phosphodiesterases, nuclear hormone receptors, and proteases such as deubiquitinases and other epigenetic targets.

Crystal Bank is a library of >75 proteins with known routes to structure, which can be used to speed up the analysis of your protein/ligand complexes by X-ray crystallography. Some of the proteins currently available are listed below:

Crystal Bank Proteins
KinasesEpigenetic Targets
Aurora ABRD2 BD1
Aurora C/INCENPBRD2 BD2
ALKBRD4 BD1
ASK1BRD4 BD2
ITKCREBBP
JAK2USP2
SYKPhosphodiesterases
GSK3BPDE1B
PI3K gammaPDE2A
JNK3PDE4B catalytic domain
CDK2/cyclin A2PDE4B catalytic domain + UCR
CDK2PDE4D catalytic domain
MKK7PDE5
PDHK-2PDE7B
TMK (human)PDE9A
TMK (C. albicans)PDE10A
P38 alphaOthers
TRKABcl2
ALK5Fatty acid synthase/thioesterase domain
BMXCD81
PLK4HCV polymerase
ZAP70HIV capsid
ProteasesHIV integrase
Aminopeptidase NHIV matrix
Carboxypeptidase BHIV reverse transcriptase
Caspase-1KEAP1
Caspase-6LDHA
HCV proteaseNMT (C. albicans)
uPANMT (human)
BACE-1PIN-1
MMP3hPGDS
MMP8Arginase II
ThrombinACCase (C. albicans)
HNECyclophilin A
AdipsinCyclophilin B
Nuclear Hormone ReceptorsCyclophilin D
Androgen receptorFKBP12
Estrogen receptor alphaP450 2C9
Estrogen receptor betaP450 3A4
PPAR delta