Medicinal Chemistry in Drug Discovery

Our medicinal chemistry team is world-class, with many of our scientists bringing a wealth of experience from previous employment in the pharmaceutical and biotechnology industries. With our exposure to a wide range of therapeutic areas and collaborative working styles, we are well equipped to drive your program forward. We have an enviable record of delivering over 75 development candidates to our partners, and the strength and consistency of our innovation is exemplified by inventorship on over 320 patent applications filed by clients.

With expertise in early target identification, hit-finding strategies, hit-to-lead, lead optimization, patent strategy, and preparation for IND filing, we work with you to understand your requirements and deliver development candidates that meet agreed target product profiles. As programs progress, we are able to call on additional in-house scientific disciplines including structural biology, in vitro biology, DMPK, in vivo pharmacology, pharmaceutics/formulation, and safety assessment. Our highly experienced computational chemistry group is also on hand to deploy a full range of in silico tools to support the design process and assist in the continuous interpretation of in vitro and in vivo data.

Our scientists can also draw upon the wider Charles River organization to help progress your development candidate towards the clinic. This collaborative, integrated approach to drug discovery ensures that your program: 

  • Stays focused on achieving your goals and delivers to your budget 
  • Benefits from our the accumulated knowledge and experience 
  • Maximizes efficiency by accessing the widest range of services 
  • Minimizes turnaround times without compromising quality 
  • Establishes and protects intellectual property