Charles River can measure the solubility, dissolution and stability of compounds under a variety of conditions. This data, together with Caco-2 permeability measurements produced by in vitro ADME screening, can be used to provide an early Biopharmaceutics Classification System (BCS) class for a compound.


  • Kinetic solubility measurement
  • Thermodynamic solubility measurement
  • pH solubility measurement
  • Solubility/Stability measurements in lung, gastric and intestinal fluid mimetics
  • BCS classification in conjunction with Caco-2 permeability measurements
  • Dissolution of API and early IMP formulations (paddle and flow-through)