Hit-to-Lead Optimization and Hit Expansion

Achieving a lead candidate is challenging. Charles River scientists will work closely with you to define the compound profile required, prioritize compounds for detailed evaluation, and interpret results from a customized screening cascade. This includes primary target and cellular activity together with ADME/PK assessment and target engagement biomarker assay development.

Track Record of Candidates

Charles River chemistry, biology, large molecule and small molecule screening scientists deliver patents and compound candidates in many therapeutic areas including oncology, neurology, immune-oncology, pain, inflammation and respiratory to our drug discovery cro clients.Successful candidate development is directly related to the experience of scientists, investment in platform technologies and application of a translational approach. Check out our candidate delivery and patent track record by therapeutic area. Will our next discovery be yours?

The Charles River chemistry team can guide key decisions at the hit generation and hit expansion stage by considering factors such as compound stability for in vivo studies, solubility, and other poor property issues, weak exposure in an animal, and off-target selectivity. As seen in the above chart, Charles River has an extensive track record of delivering high-quality lead series to our clients within agreed timelines across a broad range of target classes and therapeutic areas.


    Integrated Drug Discovery Seminar Series

    Attend the seminar to learn how Charles River’s integrated drug discovery programs have reduced this timeline through industry experienced, multi-disciplinary teams focused on resource efficiency, scientific excellence and strategic partnerships with clients through all aspects of drug discovery.

    Charles River chemistry and biology leaders host seminars throughout the year to share data and present case studies on how to optimize the drug discovery workflow.

    Check for a location near you


    Hit-to-Lead Activities

    Charles River is a hit-to-lead CRO, offering flexible, customized hit2lead services. Business models include stand-alone, fee-for-service pricing, and fully integrated solutions. Driven by your needs, projects may feature one or more of the following:

    • Design and synthesis of new analogues for rapid SAR determination
    • Increasing compound potency and selectivity
    • Improvement of drug-like properties
    • Applying CADD to generate binding hypotheses and to investigate SAR
    • Early assessment of ADME properties
    • Chemical synthesis
    • Evaluation of target engagement biomarker assays
    • Ranking of hits or hit series for lead optimization

    Consult with a Hit-to-Lead expert


    Hit-to-Lead Frequently Asked Questions (FAQs)