We will work closely with you to define the compound profile required, prioritizing compounds for detailed evaluation and interpreting results from a customized screening cascade including primary target and cellular activity together with ADME/PK assessment and target engagement biomarker assay development. Our medicinal chemists have an impressive track record of delivering high-quality lead series to our clients within agreed timelines across a broad range of target classes and therapeutic areas.
- Design and synthesis of new analogues for rapid SAR determination
- Increasing compound potency and selectivity
- Improvement of drug-like properties
- Applying CADD to generate binding hypotheses and to investigate SAR
- Early assessment of ADME properties
- Evaluation of target engagement biomarker assays
- Ranking of hits or hit series for lead optimization