Hit-to-Lead Services

We will work closely with you to define the compound profile required, prioritizing compounds for detailed evaluation and interpreting results from a customized screening cascade including primary target and cellular activity together with ADME/PK assessment and target engagement biomarker assay development. Our medicinal chemists have an impressive track record of delivering high-quality lead series to our clients within agreed timelines across a broad range of target classes and therapeutic areas.

Hit Generation Activities

  • Design and synthesis of new analogues for rapid SAR determination
  • Increasing compound potency and selectivity
  • Improvement of drug-like properties
  • Applying CADD to generate binding hypotheses and to investigate SAR
  • Early assessment of ADME properties
  • Evaluation of target engagement biomarker assays
  • Ranking of hits or hit series for lead optimization