NZB/W Mouse Model
Charles River has characterized a clinically relevant model of lupus, the NZB/W mouse. In this model, lupus develops spontaneously with an increase in autoantibodies at 5 months of age and peak at 8-9 months, which parallels with development of proteinuria, an indicator of kidney dysfunction.
We also offer other kidney models of inflammation, such as our Nephrotoxic Antiserum Mouse Model of Nephritis.
Study parameters include in-life clinical evaluation of proteinuria and serum autoantibodies, blood creatinine, and histopathological evaluation of kidney sections together with optional cytokine analysis in serum and kidneys.
Optional Study Endpoints
- PK/PD blood collections
- Cytokine/chemokine analysis
- Clinical chemistry
- Histopathological evaluation
- Flow cytometry in lymph nodes or spleen