Validated Musculoskeletal Disease Models

Our integrated approach allows the comprehensive evaluation of bone and cartilage drug efficacy, musculoskeletal tissue healing and biocompatibility, orthopedic device efficacy, and the effects of new orthobiologic applications.

Joint/Cartilage Repair Models

  • Articular cartilage repair
  • Anterior cruciate ligament (ACL) repair
  • Osteoarthritis (OA)
  • Rheumatoid arthritis
  • Meniscal repair/replacement
  • Reconstruction/fixation of ligaments and tendons

Bone Fracture/Defect Repair Models

  • Gonadectomy (ovariectomy and orchiectomy)-induced bone loss for osteoporosis drug testing
  • 5/6 nephrectomy
  • TPTx (thyroparathyroidectomy)
  • Schenk model in weanling rats (screen for antiresorptive agents)
  • Critical/non-critical segmental defects
  • Tibial/femoral/ulnar osteotomy
  • Maxillofacial/mandibular defects
  • Dental implants
  • Autograft/allograft/bone graft substitute implantation
  • Bone ingrowth for joint replacement
    • Non-weight-bearing (axial and transcortical) defects
  • Bone cement, putty, and implantation
  • Critical size defect with mechanical testing
    • Radial defect
    • Ulnar defect
    • Femoral defect
    • Calvaria defect
    • Tibial defect

Spinal Fusion & Spinal Instability/Fixation Models 

  • Spinal surgery/bone reconstruction
  • Posterolateral/interbody fusion
  • Intervertebral disc reconstruction
  • Discectomy/disc replacement
  • Spine intervention

Note: Non-GLP efficacy models are also available for your early research.

Support Services

  • Imaging using bone densitometry techniques
  • Biochemical markers of bone and cartilage turnover
  • Radiographic diagnostics (X-ray)
  • Histomorphometry and histology
  • Biomechanical strength testing
  • Micro-CT scanning