Change the Course of Alzheimer’s Disease Research

Take a fresh approach to your Alzheimer’s Disease research with optimized in vitro and in vivo models and assays that provide actionable data to drive your drug development from early discovery through late-stage preclinical. Start with any of our cell-based models, transgenic mouse models, aged rat and mouse models, and amnesia models which display pathologies associated with Alzheimer’s Disease (AD). Keep going and breakthrough with our advanced platform of neuroscience translational tools and assays. From cognitive neuroscience studies to AD-associated pathology, get the data you need with our most advanced neurological imaging techniques, behavioral testing platforms and electrophysiology tools.


Alzheimer's Disease Research Tools

Cell-based phenotypic screens

Behavior efficacy and phenotyping

  • Sensory motor function
  • Gait and balance changes 
  • Cognitive changes
  • Social interaction

Neurological Imaging

  • T2-MRI for volumetric analysis
  • Proton magnetic resonance spectroscopy (1H-MRS)
  • Pharmacological MRI

Biomarkers identification

  • Immunohistochemistry of amyloid plaques, phosphorylated Tau, GFAP, Iba1 and other markers
  • BrdU incorporation as a measure of cell proliferation
  • Cytokine expression
  • Soluble Amyloid beta peptide measurement
  • Neurochemical profiling by microdialysis (ACh, 5HT, NE, DA, Glu and other metabolites)
  • Microdialysis sampling and bioanalysis for PK studies
  • Quantification of biomarkers, amyloid plaques and neuron counts by Stereology
Image of person looking at resources on a computer with a cup of coffee. Charles River has many resources for your Alzheimer's Disease research

Alzheimer’s Disease Resources

Check out our Alzheimer’s Disease posters, publications and other scientific resources…

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  • In Vitro Cell-based Assays

    The proper combination of Alzheimer’s disease in vitro assays can deliver critical information delivering insights that serve as better predictors for the transition to in vivo studies. Improve your in vivo success by integrating translational cell-based assays from simple cell proliferation and viability assays to multicellular biochemical and functional assays for high content phenotypic screening using our unique access to Alzheimer’s Disease relevant human primary cells from tissue, blood and differentiated stem cells into your AD discovery program.

  • Transgenic Mouse Models

    The Tg2576 Alzheimer's Disease model overexpress this mutant form of amyloid precursor protein. The 5xFAD mouse model expresses human APP and PSEN1 transgenes with a total of five AD-linked mutations. Both available models are validated using multiple endpoints including cognitive testing, measurement of the levels of soluble and insoluble beta amyloid, and biomarker measurement using immunohistochemical staining.

  • Scopolamine-induced Amnesia Model

    Disruption of the cholinergic system leads to amnesia or memory loss. This Alzheimer’s animal study employs Scopolamine, a muscarinic cholinergic receptor antagonist providing a validated animal model to study impaired learning and memory in Alzheimer’s Disease research.

  • Large Animal Models

    Our Alzheimer's Disease models include large animal models that are used to study higher cognitive function and changes. Large animal models are evaluated using a broad range cognitive test battery that is similar to the CANTAB touchscreen testing methods used in humans.

Fluorescence view of rat brain slice used in Alzheimer's Disease Research Studies.

Characterization of Alzheimer’s Disease Animal Models

Breakthrough your Alzheimer’s Disease research by using these advanced tools to assess next-generation therapeutics.

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Frequently Asked Questions (FAQs) for Alzheimer's Disease Research