Hemodynamic MRI Studies

Hemodynamic MRI comprises a broad range of modalities that may be utilized in any indication with a vascular component, including naïve animals, models of stroke, traumatic injury, neurodegenerative diseases like Alzheimer’s disease, hypoperfusion, and ventricular assist devices (VADs).

Charles River’s capabilities include perfusion imaging to measure relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF). Imaging CBV uses contrast agents like monocrystalline iron oxide nanoparticles. This method generates gradient-echo and spin-echo sequences that are sensitive to different blood vessel diameters. CBF uses Gadolinium to track blood flow, blood volume, and mean transit time. Additionally, we offer time-of-flight magnetic resonance angiography (ToF-MRA) to detect vascular structure malformations using 2D and 3D imaging. This method requires the use of contrast agents.

blood brain barrier leakage via full brain mapping
Figure 1: Gadolinium contrast agent enhanced MRI used to detect blood brain barrier leakage via full brain mapping. When the blood brain barrier is compromised, the large Gadolinium molecule can leak into the brain.