Preclinical Oncology Research

Charles River has dedicated teams of oncology and immunology experts to design the best preclinical efficacy oncology studies for you. At the initiation of each study, a dedicated team is assigned to manage everything from design through execution. Our teams consist of scientists, technical personnel, a study director, and a project manager with each taking an active role to ensure seamless communication and flexibility for the duration of your study.

Image of tumor for AACR 2021 signifying the oncology research done at Charles River

AACR Annual Meeting 2021

No matter the circumstances, cancer patients are waiting on new therapies. Browse this year's collection of scientific posters and resources so your oncology research can continue moving forward.

Keep Moving Forward

End-to-end Oncology Studies

By working with Charles River throughout preclinical oncology research, we can help ensure your preclinical oncology studies are designed optimally for faster entrance to the clinic:

Chemistry services for oncology research is vital in order to optimize the best version of your compound.

Chemistry services: By working with our chemists right from the beginning, you can optimize the best version of your compound.


Cell biology assays in both 2D and 3D formats can be used to aid oncology research

In vitro cell biology assays: 2D and 3D cell assays using patient-derived materials and the cells of the tumor microenvironment allow us to accurately model human cancers.


Predictive immunotoxicology assays and models mitigate risk of oncology drug discovery by identifying potential unwanted immune reactions

Predictive immunotoxicology: Assays and models to mitigate risk of progressing your drug.


In vivo pharmacodynamic (PD) screens allow the function to be evaluated, and whether the is immune modulation, before entering disease specific models

In vivo pharmacodynamic screening models: To allow the function of a therapeutic to be examined before entering a disease-specific model.


in vivo efficacy models, for example breast cancer models, can be used to evaluate potential anti-cancer compounds

In vivo oncology efficacy models: You can test your drug in fully characterized patient-derived xenografts in our custom humanized mouse model, with the option to implant as orthoptopic models for greater disease relevance, to truly represent the human disease state.


Metastasis of cancerous cell.

Oncology analysis: Ex vivo services, such as tumor microdialysis, sample the tumor microenvironment to further aid in your decision making.


Safety assessment and toxicology is valuable for oncology research to ensure the best version of the drug is advanced to the clinic.

Safety assessment and toxicology: Our extensive regulatory knowledge aids translation to the clinic, which is especially important for cell and gene therapies where discovery and safety studies will be closely linked.


Clinical sample analysis and clinical biomarker analysis services supports the decision to progress your oncology drug.

Clinical biomarkers: Biomarker efficacy data generated in early phase clinical trials further supports the decision to progress.


Human Translational Oncology Studies

Each study is designed to ensure the best version of your drug is progressed to the clinic. Many therapies fail later in the drug development pipeline due to lack of efficacy or proof of mechanism of action (MOA), and with a rise in focus on novel modalities, there are increasingly complex interactions with the patient and their immune system. Therefore, it is vital to test therapies as early as possible in models and assays that mirror the patient environment.

3D illustration of a Macrophage cell used in preclinical oncology research

Article - Immuno-oncology Integrated Approaches

Discover how integrated approaches can drive clinical success for biologics and small molecule modulators.

Read the article

By choosing the most relevant models, it allows MOA to be established as early as possible, mitigating risk of progressing prematurely to the next stage, and allows continued monitoring of target engagement throughout the drug discovery process for more informed decisions.

We can leverage many of our proprietary patient-derived xenograft (PDX) models and cell lines to perform integrated preclinical profiling of anticancer agents. Many of the models in our library correspond to established cell lines that have been derived from the xenograft model. This unique capability enables you to use the same tumor entity throughout your 2D in vitro, 3D ex vivo, and in vivo PDX assays. This approach to your program keeps efficiency and cost in mind, while letting you quickly collect the best study data.

By using the same tumor model in your assays, we can leverage our extensive cancer model database, and offer insight and clinically relevant information throughout the life of your study.

Partner with a CRO who anticipates your needs with delivery of fast, flexible service and a proven ability to take therapies from discovery to market. We are true experts in oncology with over 20 years’ experience, allowing us to support drug discovery across the pipeline and across the full range of modalities and targets.

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Frequently Asked Questions (FAQs) about Preclinical Oncology Studies