CDX Models for Oncology Studies
Our cell line-derived xenograft CDX models are run as subcutaneous, disseminated, or orthotopic in both mice and rats. Human tumor cell line-derived xenografts in the immunodeficient nude rat model are used to conduct in vivo efficacy evaluation of potential cancer therapies. The nude rat xenograft model is well suited for tumor studies, as it closely mimics human disease state and has similar physiology and metabolic characteristics to humans. This model can be used to evaluate targeted therapy, cytotoxic drugs, antibody therapies, and viral therapies.
Our broad range of tumor lines gives you a wide variety of testing alternatives. We evaluate our tumor xenograft portfolio on a regular basis for response to standards of care and store data to aid the design of combination studies.
In addition to helping you select the most appropriate model for your agent, our scientific staff can fully profile your agent in a variety of tumor types or in combination with the appropriate clinical agent. When you’re ready to prepare your IND filing, we offer our CDX rat models as a second species, in addition to our mouse CDX models.
Our full range of cell lines in multiple tumor histotypes is listed below. Need something different? Contact our team; we are happy to develop a specific cell line and CDX rat model at your request.
| Tumor Type | Cell Line |
|---|---|
| Brain | U87MG |
| Breast | MDA-MB-231 |
| Colon | HCT116, HT29 |
| Epidermoid | A431 |
| Leukemia | MV4-11, RS4;11, THP-1 |
| Lung | H460 |
| Melanoma | A2058, A375 |
| Ovarian | A2780 |
| Pancreatic | MiaPaCa-2 |
| Prostate | PC3 |
Efficacy evaluation in CDX rat models can be combined with:
- Hematology (CBC/Diff) analysis
- Pharmacokinetic or bioavailability sampling and analysis
- Histopathology or tissue sampling
- Biomarker screening, sampling or evaluation
- Supporting in vitro 2D assays and 3D ex vivo screening models
If you’re looking to purchase oncology research models for use in your own efficacy studies, please visit our research models pages or see our xenograft data collection for help in selecting the best animal model.
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Frequently Asked Questions (FAQs) for CDX models:
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What is a cell line-derived xenograft (CDX) rat model?
A cell line-derived Xenograft or CDX model is used for the research and testing of anti-cancer therapies. Human tumor samples are cultured as cell lines and implanted into immunodeficient nudes to test the efficacy of anti-tumor compounds in vivo.
The nude rat CDX model has multiple advantages over other models as they closely mimic human disease; it is a larger animal and therefore metabolically and physiologically more similar to humans, they grow larger tumors for analysis and metastatic studies. Because it is immunodeficient, it can be used with patient-derived materials.
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Why should I run my CDX rat model studies with Charles River?
Charles River’s wide range of cell lines and tumor histotypes, and our expertise in a range of in vivo oncology models, make us the ideal partner to run your cell line-derived xenograft (CDX) model studies. In addition to our CDX models in mice we also offer rat CDX models as a second species for clients preparing IND filing.
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Which oncology model is right for me?
We offer a broad range of in vivo oncology models including our CDX models, syngeneic and PDX models, in addition to supporting in vitro 2D assays and 3D ex vivo screening models. With so many to choose from, selecting the right one for your study can be a daunting task. Our Tumor Model Compendium or model finder tool is a great place to start. Still need help? Contact us. Our team is happy to guide your decision.