Humanized Mouse Models

Charles River offers two study platforms using humanized mouse models (NOG, NSG, and NCG) engrafted with CD34+ or PBMC. Our models have been characterized with known immune checkpoint inhibitors of clinical relevance to help take the next step in evaluating your compound in immuno-oncology.

Humanized mouse models can be used for tumor models to screen cancer therapies in an intact human immune system.
Figure 1: Schematic of Humanized mouse tumor models. The mouse immune systems are humanized by irradiating and destroying the host immune system and introducing human immune cells.

We have validated our patient-derived xenograft models as well as our human xenograft portfolio.

HSC derived from umbilical cord; multiple donors in each cohort. A single cohort of animals can engraft with a single donor.
~Week 15: > 25% huCD45 blood cells Week 3: ~30% huCD45 blood cells
T cell focused T cell focused
Long-term studies (no GvHD) Short-term studies due to GvHD
Number of T cells may vary with multiple donors GvHD onset varies with donor
  Less costly approach

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These models can be combined with a variety of tools to enhance your study outcomes, such as:

Learn about Charles Rivers Novel Humanized Mouse Model

NCG mouse.

NCG/CRL as a novel (Charles River) humanized mouse model for pre-clinical oncology studies: immunophenotypic characterization and performance monitoring

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Do you need a humanized mouse model? Charles River offers various options depending on your location. Click here to learn more